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Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

NCT ID: NCT00731159

Last Updated: 2008-08-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-07-31

Study Completion Date

2009-07-31

Brief Summary

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Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments

Detailed Description

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Capacitation is a physiologic process in which the sperm acquire the potential to fertilize oocytes. Capacitation can be measured, but the available technics are expensive, inaccurate and complex. A new method to evaluate sperm capacitation was developed in Bar Ilan University, Israel. We intend to measure the capacitation of semen that is used for fertilizing human oocytes in patients treated at the IVF unit at Assaf Harofeh Medical Center.By this, to evaluate the potential of the new method to predict human oocyte fertilization.If the method will be found valuable, it will enable to develop new drugs/methods that may improve sperm capacitation and by this to improve oocyte fertilization leading to more embryos, pregnancies and deliveries.

Conditions

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Sperm Capacitation

Study Design

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Study Time Perspective

PROSPECTIVE

Study Groups

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A

Sperm capacitation:

Sperm capacitation is measured in a sample of the same ejaculated sperm unit given for fertilizing human oocytes in an IVF treatment cycle

sperm capacitation

Intervention Type BIOLOGICAL

sperm capacitation measured at Bar Ilan University

biologic

Intervention Type OTHER

sperm synthesis of G-actine to F-actine

sperm capacitation

Intervention Type OTHER

sperm synthesis of G-actine to F-actine

Interventions

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sperm capacitation

sperm capacitation measured at Bar Ilan University

Intervention Type BIOLOGICAL

biologic

sperm synthesis of G-actine to F-actine

Intervention Type OTHER

sperm capacitation

sperm synthesis of G-actine to F-actine

Intervention Type OTHER

Other Intervention Names

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sperm capacitation sperm synthesis of G-actine to F-actine

Eligibility Criteria

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Inclusion Criteria

* Patients requiring IVF within the "routine" work of an IVF Unit
* normo-responding woman
* non ICSI cycles

Exclusion Criteria

* Patients undergoing ICSI only cycle
* Low responders-less than 8 oocytes
* Male patients with low semen volume
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assaf-Harofeh Medical Center

OTHER_GOV

Sponsor Role lead

Responsible Party

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Assaf Harofeh MC

Locations

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Assaf Harofeh MC

Beer Yaacov, Zerifin, Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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arieh raziel, prof

Role: CONTACT

Phone: 97289779005

Email: [email protected]

raphael ron-el, prof

Role: CONTACT

Phone: 97289779005

Email: [email protected]

Facility Contacts

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arieh raziel, prof

Role: primary

raphael ron-el, prof

Role: backup

Other Identifiers

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54/08

Identifier Type: -

Identifier Source: org_study_id