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Laser-Assisted Versus Conventional Intracytoplasmic Sperm Injection

NCT ID: NCT00114725

Last Updated: 2005-06-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-03-31

Study Completion Date

2004-10-31

Brief Summary

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Laser-assisted intracytoplasmic sperm injection (ICSI) has been suggested as a more effective alterative to conventional ICSI when this method of insemination is indicated for patients undergoing in vitro fertilization (IVF). Laser-assisted ICSI differs from conventional ICSI in that a laser is used to drill a small hole through the hard outer coating surrounding an egg before the injection needle containing a single sperm is inserted into the egg. The hole eliminates compression of the egg that normally occurs with conventional ICSI, and thus may reduce the chance of damage. Laser-assisted ICSI is hypothesized to result in increased egg survival, and perhaps improved embryo quality, compared to conventional ICSI.

Detailed Description

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Conditions

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Infertility Infertility, Male

Keywords

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In Vitro Fertilization Intracytoplasmic Sperm Injection Oocytes Zona Pellucida Oolemma Fertilization Preimplantation Embryo Development

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Laser-assisted intracytoplasmic sperm injection

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of infertility
* Scheduled for IVF with ICSI

Exclusion Criteria

* Retrieval of fewer than 6 mature oocytes
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shady Grove Fertility Reproductive Science Center

OTHER

Sponsor Role lead

Principal Investigators

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Alana Davis, BS

Role: PRINCIPAL_INVESTIGATOR

Shady Grove Fertility Reproductive Science Center

Kevin S Richter, PhD

Role: STUDY_DIRECTOR

Shady Grove Fertility Reproductive Science Center

Locations

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Shady Grove Fertility Reproductive Science Center

Rockville, Maryland, United States

Site Status

Countries

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United States

References

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Mikhailusov SV, Bart BIa, Siluianov SV, Mikhailusova MP, Nikolaeva AS. [Duodenogastric reflux and gastric pathology in the elderly patients]. Eksp Klin Gastroenterol. 2010;(12):54-9. Russian.

Reference Type BACKGROUND
PMID: 21560622 (View on PubMed)

Kurashige H, Cateau H. Dendritic slow dynamics enables localized cortical activity to switch between mobile and immobile modes with noisy background input. PLoS One. 2011;6(9):e24007. doi: 10.1371/journal.pone.0024007. Epub 2011 Sep 8.

Reference Type BACKGROUND
PMID: 21931635 (View on PubMed)

Chand AL, Wijayakumara DD, Knower KC, Herridge KA, Howard TL, Lazarus KA, Clyne CD. The orphan nuclear receptor LRH-1 and ERalpha activate GREB1 expression to induce breast cancer cell proliferation. PLoS One. 2012;7(2):e31593. doi: 10.1371/journal.pone.0031593. Epub 2012 Feb 16.

Reference Type BACKGROUND
PMID: 22359603 (View on PubMed)

Semiglazov VF, Paltuev RM, Remizov AS, Semiglazov VV, Dashian GA, Bessonov AA, Pen'kov KD, Vasil'ev AG, Semiglazova TIu, Kolar'kova VV. [The role of nanotechnology in creating novel antitumor agents]. Vopr Onkol. 2011;57(5):636-40. Russian.

Reference Type BACKGROUND
PMID: 22238935 (View on PubMed)

Rienzi L, Ubaldi F, Martinez F, Minasi MG, Iacobelli M, Ferrero S, Tesarik J, Greco E. Clinical application of laser-assisted ICSI: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2004 Jul 1;115 Suppl 1:S77-9. doi: 10.1016/j.ejogrb.2004.01.017.

Reference Type BACKGROUND
PMID: 15196721 (View on PubMed)

Other Identifiers

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P2004-1

Identifier Type: -

Identifier Source: org_study_id