Pharmacokinetics of Carnosine

NCT ID: NCT00721708

Last Updated: 2009-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-04-30

Study Completion Date

2008-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The absorption kinetics of dietary carnosine (β-alanyl-L-histidine) will be determined in the healthy adults.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Oxidative Stress

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

histidine dipeptides carnosine anserine

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Intervention Model

CROSSOVER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Carnosine(450 mg)

Group Type EXPERIMENTAL

pure carnosine

Intervention Type DIETARY_SUPPLEMENT

one time dose of pure carnosine (450 mg)

2

Beef (150g)

Group Type EXPERIMENTAL

Beef

Intervention Type OTHER

one time dose, 150 g of beef

3

chicken (150g)

Group Type EXPERIMENTAL

Chicken

Intervention Type OTHER

One time dose, 150g of chicken breast

4

Chicken broth (obtained from 150 g of chicken breast)

Group Type EXPERIMENTAL

Chicken broth

Intervention Type OTHER

one time dose of chicken broth obtained from 150g of chicken breast

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

pure carnosine

one time dose of pure carnosine (450 mg)

Intervention Type DIETARY_SUPPLEMENT

Beef

one time dose, 150 g of beef

Intervention Type OTHER

Chicken

One time dose, 150g of chicken breast

Intervention Type OTHER

Chicken broth

one time dose of chicken broth obtained from 150g of chicken breast

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Healthy adult
* normal hematological parameters, normal serum albumin, normal liver function, normal kidney function

Exclusion Criteria

* History of smoking or alcoholism
Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Tufts University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Tufts University

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Kyung-Jin Yeum, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Tufts Medical Center

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University

Boston, Massachusetts, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

Yeum KJ, Orioli M, Regazzoni L, Carini M, Rasmussen H, Russell RM, Aldini G. Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans. Amino Acids. 2010 Mar;38(3):847-58. doi: 10.1007/s00726-009-0291-2. Epub 2009 Apr 19.

Reference Type RESULT
PMID: 19381778 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

TMC/TUHS IRB 7737

Identifier Type: -

Identifier Source: org_study_id