Determination of the Bioavailability of Short Chain Fatty Acids in Healthy Humans
NCT ID: NCT01757379
Last Updated: 2015-01-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2011-04-30
Brief Summary
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In addition the level of acetate, propionate and butyrate production from inulin will be determined using the principle of isotope dilution.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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13C-labeled acetate
13C-labeled Acetate
400 mg of sodium acetate 1-13C (2 colon delivery capsules with 200 mg)
13C-labeled propionate
13C-labeled propionate
340 mg of sodium propionate 1-13C (2 colon delivery capsules with 170 mg)
13C-labeled butyrate
13C-labeled butyrate
990 mg sodium butyrate 1-13C (2 colon delivery capsules with 495 mg)
Inulin
Inulin
15 g of inulin dissolved in 200 ml of water
Interventions
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13C-labeled Acetate
400 mg of sodium acetate 1-13C (2 colon delivery capsules with 200 mg)
13C-labeled propionate
340 mg of sodium propionate 1-13C (2 colon delivery capsules with 170 mg)
13C-labeled butyrate
990 mg sodium butyrate 1-13C (2 colon delivery capsules with 495 mg)
Inulin
15 g of inulin dissolved in 200 ml of water
Eligibility Criteria
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Inclusion Criteria
* Regular dietary pattern (3 meals/day)
* Age: 18-65y
* BMI: 18,5-27 kg/m2
Exclusion Criteria
* Abdominal surgery in the past, with the exception of appendectomy
* Intake of medication influencing the gastro-intestinal system 14 days prior to the study
* In treatment at a dietician
* Intake of pre- and/or probiotics
* Exposure to radioactivity 1 year prior to the study
* Serious chronic disease of the gastrointestinal tract
* Use of medication that affects the gastro-intestinal tract during the last 2 weeks prior to the study
* Pregnancy, pregnancy desire or lactation
* Blood donation during the last 3 months prior to the study
* Diabetes (type 1 or 2)
* Aberrant hemoglobin level (Hb) in blood. Normal between 14.0 and 18.0 g/dL for men and between 12.0 and 16.0 g/dL for women
18 Years
65 Years
ALL
Yes
Sponsors
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KU Leuven
OTHER
Responsible Party
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Kristin Verbeke
Professor K. Verbeke
Principal Investigators
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Kristin Verbeke, Professor
Role: PRINCIPAL_INVESTIGATOR
KU Leuven
Locations
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KU Leuven/ UZ Leuven
Leuven, Vlaams-Brabant, Belgium
Countries
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Other Identifiers
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ML5768
Identifier Type: -
Identifier Source: org_study_id
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