Influence of Food Matrix on Prebiotic Efficacy in Inulin Type Fructans
NCT ID: NCT05581615
Last Updated: 2022-12-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
96 participants
INTERVENTIONAL
2020-11-20
2021-10-06
Brief Summary
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Does the food matrix influence the prebiotic effect of chicory-derived inulin in terms of stimulation of bifidobacteria in the gut microbiota Participants will receive one of three food items containing inulin or pure inulin dissolved in water daily for 10 days. The food items or pure inulin powder will deliver 10 g/d inulin split into two dosages of 5 g/d. They will provide stool samples before and at the end of the intake period. They will record any gastrointestinal sensations and bowel habits in a diary. Urinary samples will be collected at baseline and end of intervention for analysis of metabolites with Nuclear Magnetic resonance (NMR).
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Pure inulin
2 x 5 g/d inulin
Inulin
Each intervention provided 10 g/d inulin split into two dosages of 5 g.
Shortbread containing inulin
2 x per day shortbread containing 5 g inulin per serving
Inulin
Each intervention provided 10 g/d inulin split into two dosages of 5 g.
Rice drink containing inulin
2 x per day rice drink containing 5 g inulin per serving
Inulin
Each intervention provided 10 g/d inulin split into two dosages of 5 g.
Milk chocolate containing inulin
2 x per day milk chocolate containing 5 g inulin per serving
Inulin
Each intervention provided 10 g/d inulin split into two dosages of 5 g.
Interventions
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Inulin
Each intervention provided 10 g/d inulin split into two dosages of 5 g.
Eligibility Criteria
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Inclusion Criteria
* Volunteer is aged ≥ 18 to ≤ 65 years at the time of pre-examination
* Volunteer's BMI is ≥ 18,5 and ≤ 29,9
* Volunteer follows an average Western European diet
* Volunteer has a stool frequency of at least 3 bowel movements per week
* Volunteer is able and willing to comply with the study instructions
* Volunteer is suitable for participation in the study according to the investigator/study personnel
* Written informed consent is given by volunteer
Exclusion Criteria
* Gastrointestinal disorders including irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) or other conditions that might affect the gut environment
* Food allergies or intolerances
* Vegetarians, vegans and/or extreme diets including high protein/fibre, ketogenic, intermittent fasting and/or carnivore
* Using drugs (e.g. antibiotics, aspirin, proton pump inhibitors) influencing gastrointestinal function (8 weeks before intervention)
* Use of laxatives and labelled pre- and probiotics in the previous 4 weeks before the beginning of intervention
* Clinically significant diabetes
* Volunteers currently involved or will be involved in another clinical or food study
* History of drug (pharmaceutical or recreational) or alcohol abuse.
* Has received bowel preparation for investigative procedures in the 4 weeks prior to the study
* Has undergone surgical resection of any part of the bowel.
* If participants are pregnant or are lactating
18 Years
65 Years
ALL
Yes
Sponsors
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University of Reading
OTHER
Beneo-Institute
INDUSTRY
Responsible Party
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Principal Investigators
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Robert A Rastall, Prof
Role: PRINCIPAL_INVESTIGATOR
University of Reading
Locations
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University of Reading
Reading, , United Kingdom
Countries
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Other Identifiers
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STUDY Number - 36/2020
Identifier Type: -
Identifier Source: org_study_id