fMRI in Blood Phobia Syncope

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2010-06-30

Study Completion Date

2010-06-30

Brief Summary

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We plan to study patient who faint in response to the sight of blood and compare them to healthy subjects who do not. We are going to use a special type of MRI scan (functional MRI) to determine if there are differences in brain activation in response to seeing bloody or gory pictures that occur before the fainting occurs.

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Detailed Description

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Another aim of the study is to determine whether or not differences in personality traits among people with blood phobia is associated with differences in BOLD signal responses during fMRI.

Conditions

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Syncope Blood Injury Phobia Autonomic Dysfunction

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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2

Healthy control subjects (who do not faint at the sight of blood)

fMRI Scan

Intervention Type PROCEDURE

Subjects will undergo a functional MRI scan of the head lasting \~45 minutes. They will be repeatedly shown video clips of blood, other disgusting things, or are neutral.

1

People who faint at sight of blood

fMRI Scan

Intervention Type PROCEDURE

Subjects will undergo a functional MRI scan of the head lasting \~45 minutes. They will be repeatedly shown video clips of blood, other disgusting things, or are neutral.

Interventions

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fMRI Scan

Subjects will undergo a functional MRI scan of the head lasting \~45 minutes. They will be repeatedly shown video clips of blood, other disgusting things, or are neutral.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 18-30 years of age
* 1\. History of at least one syncopal episode upon exposure to viewing blood (Case Group)
* Negative urine pregnancy test on study day

Exclusion Criteria

* Vasoactive medications (within 2 weeks of study day)
* antihypertensives
* beta blockers
* vasoconstrictors
* Psychotropic medications (within 4 weeks of study day)
* History of psychostimulant or opiate use
* History of alcohol, benzodiazepine or cannabis abuse or dependence

Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes