Brain Blood Flow Studies of Language and Memory

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

303 participants

Study Classification

OBSERVATIONAL

Study Start Date

1991-05-31

Study Completion Date

2003-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain.

When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Knowing these facts, researchers can use radioactive water (H215O) and PET scans to observe what areas of the brain are receiving more blood flow.

This study is designed to use positron emission tomography (PET) with radioactive water (H215O) to determine the areas of the brain associated with memory and language. Patients participating in the study will be made up of normal volunteers, patients with epilepsy, and patients with other abnormalities related to the surface of the brain (non-epileptic focal cortical dysfunctions).

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

PET Scan to Map the Areas of the Brain Involved in Planning

NCT00001363

Cognition Disorders

COMPLETED

PET Scan of Brain Metabolism in Relation to Age and Disease

NCT00001972

Alzheimer's Disease Brain Neoplasm Niemann Pick Disease

COMPLETED

Positron Emission Tomography (PET) to Study Brain Signaling

NCT00044200

Healthy

COMPLETED

Metabolic Abnormalities in Children With Epilepsy

NCT00001325

Generalized Epilepsy Infantile Spasms Metabolic Disease +2 more

COMPLETED

PET Scan in Patients With Neurocardiologic Disorders

NCT00001418

Autonomic Nervous System Diseases

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This protocol will use positron emission tomography (PET) with H2015 and functional MRI to examine localization of memory and language in normal control subjects, and patients with localization-related epilepsy.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cerebrovascular Disorder Epilepsy

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

15 O Water

Intervention Type DRUG

FDG

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Normal Volunteers:

The desired age range is 18 to 55 years.

Subjects will have no history of head injury or other neurological disease and must not be taking any medication.

Female subjects of childbearing potential will be administered a pregnancy test; these subjects will not be eligible for the study requiring 2 scans.

All volunteers will read and sign the consent form.

Patients:

Patients will be selected from among those referred to the Clinical Epilepsy Section, NINDS for evaluation.

Exclusion Criteria

Patients with evidence of a progressive intracranial process, who are taking any drugs (except AEDs) that might affect the results, or active systemic disease will be excluded.

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes