Quantification of Cerebral Blood Flow by Arterial Spin Labeling in Vasospasm in Subarachnoid Haemorrhage

NCT ID: NCT02557607

Last Updated: 2015-09-23

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-12-31
• Study Completion Date: 2018-01-31

Brief Summary

A technique of MRI infusion -l'Arterial Spin Labeling-, non-invasive and non-irradiating, repeatable over time, appears promising in the field. This sequence allows for routine, generate perfusion maps relating to the entire brain volume

Detailed Description

The subarachnoid hemorrhage (SAH) is a relatively severe disease whose prognosis is particularly related to the early onset of arterial vasospasm, maximum between the 5th and 14th day after SAH. Many obstacles make it difficult screening and monitoring of such complication. The challenge is to be able to demonstrate a reduction in regional cerebral blood flow before the onset of irreversible parenchymal sequelae, responsible for the majority of long-term morbidity among survivors. In clinical routine, screening vasospasm is achieved by Doppler intracranial arteries (DTC). However, its sensitivity is poor with regard to the middle and anterior cerebral arteries. The gold standard for diagnosis is cerebral arteriography. However, vasospasm in arteriography or trans-cranial Doppler does not prejudice the appearance of a delayed ischemic deficit.

A technique of MRI infusion -l'Arterial Spin Labeling-, non-invasive and non-irradiating, repeatable over time, appears promising in the field. This sequence allows for routine, generate perfusion maps relating to the entire brain volume

Conditions

Subarachnoid Hemorrhage

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Blinding Strategy: NONE

Study Groups

Monitoring a subarachnoid hemorrhage

Any patient hospitalized at the University Hospital of Angers in neurosurgical intensive care unit for supervision by ASL and DTC a subarachnoid hemorrhage from all etiologies (excluding traumatic). An analysis of the three sessions MRI performed systematically within the first 14 days of the start of symptoms revealing the HSA will be

Group Type: OTHER

MRI

Intervention Type: DEVICE

An analysis of the three sessions MRI performed systematically within the first 14 days of the start of symptoms revealing the HSA will be

Interventions

MRI

An analysis of the three sessions MRI performed systematically within the first 14 days of the start of symptoms revealing the HSA will be

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Adults.
• Who have given their written consent.
• Affiliated to a social security system.
• Any patient hospitalized at the University Hospital of Angers in neurosurgical intensive care unit for supervision by ASL and DTC a subarachnoid hemorrhage from all etiologies (excluding traumatic).

Exclusion Criteria

• Contraindications to MRI
• patient hospitalized at the University Hospital of Angers in surgical intensive care for monitoring a subarachnoid hemorrhage.
• patient hospitalized at the University Hospital of Angers for monitoring a subarachnoid hemorrhage traumatic.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital, Angers

OTHER_GOV

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Aram TER MINASSIAN, Physician

Role: PRINCIPAL_INVESTIGATOR

UH ANGERS

Locations

CHU Angers

Angers, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Aram TER MINASSIAN, Physician

Role: CONTACT

ArTerMinassian@chu-angers.fr

02.41.35.52.31 ext. 33

Facility Contacts

Aram TER MINASSIAN, Physician

Role: primary

ArTerMinassian@chu-angers.fr

02.41.35.52.31 ext. 33

Other Identifiers

CHU-P 2013-06

Identifier Type: -

Identifier Source: org_study_id