Proving Utility of a New Field-cycling MRI Prototype in Acute Stroke Patients
NCT ID: NCT07004140
Last Updated: 2026-01-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
40 participants
OBSERVATIONAL
2025-09-16
2026-05-31
Brief Summary
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• Can FCI identify brain tissue that might recover within the first few hours after a stroke begins?
Participants will undergo a standard MRI scan and an FCI scan, as soon as possible after hospital admission.
Participants who have had a blocked blood vessel will also provide a blood sample and will have a follow up visit at 30 days for repeat of both scans and providing another blood sample.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Ischaemic stroke
Ischaemic stroke patients within 24 hours from symptom onset
3T MRI research scan
Baseline MRI scan
Field-Cycling Imaging research scan
Baseline FCI scan
Follow up 3T MRI research scan
Day 30 3T MRI scan
Follow up Field-Cycling Imaging research scan
Day 30 FCI scan
Blood samples for clotting experiments in vitro
Thrombi from whole blood from ischaemic stroke patients will be formed and examined using bench top nuclear magnetic resonance (NMR) assays. At baseline and 30 days after stroke onset.
Haemorrhagic stroke
Patients with primary intracerebral haemorrhage within 24 hours from symptom onset
3T MRI research scan
Baseline MRI scan
Field-Cycling Imaging research scan
Baseline FCI scan
Interventions
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3T MRI research scan
Baseline MRI scan
Field-Cycling Imaging research scan
Baseline FCI scan
Follow up 3T MRI research scan
Day 30 3T MRI scan
Follow up Field-Cycling Imaging research scan
Day 30 FCI scan
Blood samples for clotting experiments in vitro
Thrombi from whole blood from ischaemic stroke patients will be formed and examined using bench top nuclear magnetic resonance (NMR) assays. At baseline and 30 days after stroke onset.
Eligibility Criteria
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Inclusion Criteria
* NIHSS ≥4 and \<25 with cortical involvement and/or large vessel occlusion on baseline imaging.
* Able to undergo 3T and FCI MRI \<24h of onset.
* With or without thrombolysis.
Exclusion Criteria
* Medically unstable.
* Unable to comprehend or comply with instructions regarding scanning
* Prior mRS of \>3.
* Identified for thrombectomy.
* Non-stroke pathology or previous cortical infarct on CT scan \> 1/3 of middle cerebral artery territory.
18 Years
ALL
No
Sponsors
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NHS Grampian
OTHER_GOV
University of Aberdeen
OTHER
Responsible Party
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Locations
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University of Aberdeen
Aberdeen, , United Kingdom
Countries
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Central Contacts
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Facility Contacts
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References
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Mallikourti V, Ross PJ, Maier O, Guzman-Gutierrez G, Franko E, Lurie DJ, Broche LM, Macleod MJ. Field-Cycling MRI for Identifying Minor Ischemic Stroke Below 0.2 T. Radiology. 2024 Aug;312(2):e232972. doi: 10.1148/radiol.232972.
Senn N, Ross PJ, Ayde R, Mallikourti V, Krishna A, James C, de Vries CF, Broche LM, Waiter GD, MacLeod MJ. Field-cycling imaging yields repeatable brain R1 dispersion measurement at fields strengths below 0.2 Tesla with optimal fitting routine. MAGMA. 2025 Jul;38(3):465-474. doi: 10.1007/s10334-025-01230-w. Epub 2025 Feb 15.
Other Identifiers
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25/SS/0021
Identifier Type: OTHER
Identifier Source: secondary_id
2-001-25
Identifier Type: -
Identifier Source: org_study_id
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