Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination.

NCT ID: NCT07199920

Last Updated: 2025-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-10-01

Study Completion Date

2027-01-01

Brief Summary

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Currently, standard brain MRI takes 20 to 25 minutes, but in the case of ischemic stroke, every minute counts to limit the extension of the necrotic core, with the possibility of recanalizing the occluded artery (intravenous thrombolysis and/or mechanical thrombectomy).

The recent concept of MRI "Fingerprint" (Magnetic Resonance Fingerprinting, MRF) allows the production of a rapid single sequence and the extraction of numerous parameters.

Demonstrating the feasibility and interpretability of multimodal MRI images acquired in MRF would make it possible to consider implementing and, ultimately, replacing conventional sequences, with the aim of shortening acute stroke management times, increasing the number of sequences acquired within a short timeframe (by increasing informativeness), and thus improving patients\' short and long-term vital and functional prognosis.

Detailed Description

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Conditions

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Stroke, Ischemic

Keywords

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MRF (Magnetic Resonance Fingerprinting) stroke MRI

Study Design

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Allocation Method

NA

Intervention Model

SEQUENTIAL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Experimental

Every patient will perform classic brain MRI with additional MRF sequences.

Group Type EXPERIMENTAL

Achieva 3.0T dStream Philips

Intervention Type DEVICE

Classic and MRF sequences will be carried out on the clinical machine (Achieva 3.0T dStream Philips) of the IRMaGe platform (CHUGA, Université Grenoble Alpes, Inserm, CNRS).

Interventions

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Achieva 3.0T dStream Philips

Classic and MRF sequences will be carried out on the clinical machine (Achieva 3.0T dStream Philips) of the IRMaGe platform (CHUGA, Université Grenoble Alpes, Inserm, CNRS).

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 years
* Subacute ischemic stroke patients (\< 15 days after onset)
* Middle cerebral artery or anterior cerebral artery territory stroke
* Modified Rankin Scale (mRS) = 0-4

Exclusion Criteria

\* MRI contraindications
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Grenoble Institut des Neurosciences

OTHER

Sponsor Role collaborator

University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Loïc LEGRIS, Dr

Role: PRINCIPAL_INVESTIGATOR

[email protected]

Locations

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Chu Grenoble Alpes

Grenoble, , France

Site Status

Countries

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France

Central Contacts

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Zaza Putkaradze, Dr

Role: CONTACT

Phone: 0476767842

Email: [email protected]

Other Identifiers

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38RC23.0410

Identifier Type: -

Identifier Source: org_study_id