fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease?
NCT ID: NCT00868556
Last Updated: 2010-01-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
33 participants
OBSERVATIONAL
2009-01-31
2009-08-31
Brief Summary
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The purpose of this study is to potentially identify risk factors and/or biomarkers (which are differences in the brain structures)by comparing the brain MRI scans of migraine sufferers to brain scans of control persons to attempt to identify migraine progression using the functional MRI scans.
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Detailed Description
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At Visit 2 these same subjects will have an fMRI performed.
Subjects will be greater than age 18, have the appropriate diagnoses, be able to be consented and not be pregnant or have an inability to have the fMRI performed (have implanted metal devices, have severe claustrophobia).
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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1 episodic migraine sufferers
No interventions assigned to this group
2 chronic migraine sufferers
No interventions assigned to this group
3 non migraine sufferers (controls)
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* pregnancy
18 Years
ALL
Yes
Sponsors
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Merck Sharp & Dohme LLC
INDUSTRY
The Cleveland Clinic
OTHER
Responsible Party
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Cleveland Clinic Foundation
Principal Investigators
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Stewart J Tepper, MD
Role: PRINCIPAL_INVESTIGATOR
The Cleveland Clinic
Locations
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Cleveland Clinic Foundation
Cleveland, Ohio, United States
Countries
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References
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Wolff HG. Headache and Other Head Pain, New York: Oxford Univ Press; 1963
Welch KM, Nagesh V, Aurora SK, Gelman N. Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness? Headache. 2001 Jul-Aug;41(7):629-37. doi: 10.1046/j.1526-4610.2001.041007629.x.
Siberstein SD, Lipton RB, Solomon S, Mathew NT. Classification of daily and near-daily headaches: proposed revisions to the IHS criteria. Headache. 1994 Jan;34(1):1-7. doi: 10.1111/j.1526-4610.1994.hed3401001.x.
Silberstein SD, Lipton RB, Sliwinski M. Classification of daily and near-daily headaches: field trial of revised IHS criteria. Neurology. 1996 Oct;47(4):871-5. doi: 10.1212/wnl.47.4.871.
Bigal ME, Tepper SJ, Sheftell FD, Rapoport AM, Lipton RB. Field testing alternative criteria for chronic migraine. Cephalalgia. 2006 Apr;26(4):477-82. doi: 10.1111/j.1468-2982.2006.01128.x.
Other Identifiers
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Merck Grant IISP 36047
Identifier Type: -
Identifier Source: secondary_id
V81708
Identifier Type: -
Identifier Source: org_study_id
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