AMPLATZER Duct Occluder II Clinical Study

NCT ID: NCT00713700

Last Updated: 2019-02-04

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

192 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-08-31

Study Completion Date

2016-10-05

Brief Summary

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The objective of this study is to investigate the safety and effectiveness of the ADO II in patients with a PDA.

Detailed Description

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Conditions

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Patent Ductus Arteriosus

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Device

Group Type EXPERIMENTAL

AMPLATZER Duct Occluder II

Intervention Type DEVICE

AMPLATZER Duct Occluder II

Interventions

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AMPLATZER Duct Occluder II

AMPLATZER Duct Occluder II

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subject must have diagnosis of a PDA
* Subject must have a PDA \< 5.5mm in diameter by angiography
* Subject must have a PDA \< 12mm in length by angiography
* Subject must have a PDA \> 3mm in length by angiography
* Subject/legally authorized representative must give consent to participate in the clinical study
* Subject/legally authorized representative must consent to follow-up for the duration of the clinical study

Exclusion Criteria

* Subject must not be \< 6 kilograms for the procedure
* Subject must not be \< 6 months of age
* Subject must not be ≥ 18 years of age
* Subject must not have a descending aorta \< 10mm in diameter
* Subject must not have a right to left shunt through the patent ductus arteriosus
* Subject must not have PVR above 8 Woods units or a Rp/Rs \>0.4
* Subject must not have intracardiac thrombus
* Subject must not have additional cardiac anomalies requiring surgical or interventional correction
* Subject must not have history of more than two lower respiratory infections within the last year (i.e., pneumonia)
* Subject must not have active infection requiring treatment at the time of implant
* Subject must not have contraindication to anticoagulation treatment
* Female subjects of child bearing age must not be pregnant or desire to become pregnant within six months post implant\*
* Subject must not be participating in another study for an investigational drug and/or device that may clinically interfere with this study's endpoints

* If the subject desires to become pregnant after six months post-implant, further restriction is at the discretion of their physician.
Minimum Eligible Age

6 Months

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Children's Hospital and Health Center

San Diego, California, United States

Site Status

University of California San Francisco Hospital

San Francisco, California, United States

Site Status

The Children's Hospital - Denver

Aurora, Colorado, United States

Site Status

Alfred I. DuPont Hospital for Children -Nemours Cardiac Center

Wilmington, Delaware, United States

Site Status

Children's National Medical Center

Washington D.C., District of Columbia, United States

Site Status

Memorial Regional Hospital (Joe DiMaggio Children's Hospital)

Hollywood, Florida, United States

Site Status

Children's Healthcare of Atlanta

Atlanta, Georgia, United States

Site Status

Riley Hospital for Children

Indianapolis, Indiana, United States

Site Status

Children's Hospital Boston

Boston, Massachusetts, United States

Site Status

University of Minnesota

Minneapolis, Minnesota, United States

Site Status

University of Mississippi Medical Center

Jackson, Mississippi, United States

Site Status

Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Mount Sinai School of Medicine

New York, New York, United States

Site Status

The Children's Hospital Montefiore

The Bronx, New York, United States

Site Status

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

Site Status

The Children's Hospital at Cleveland Clinic

Cleveland, Ohio, United States

Site Status

Nationwide Children's Hospital

Columbus, Ohio, United States

Site Status

The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Vanderbilt Children's Hospital

Nashville, Tennessee, United States

Site Status

University of Texas SW Medical Center

Dallas, Texas, United States

Site Status

Texas Children's Hospital

Houston, Texas, United States

Site Status

Primary Children's Medical Center

Salt Lake City, Utah, United States

Site Status

Children's Hospital and Regional Medical Center

Seattle, Washington, United States

Site Status

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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CL00233

Identifier Type: -

Identifier Source: org_study_id

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