Expanding Patient Applicability With Polymer Sealing Ovation Alto Stent Graft Investigational Device Exemption (IDE) Study

NCT ID: NCT02949297

Last Updated: 2021-12-22

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-30

Study Completion Date

2019-03-06

Brief Summary

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A prospective clinical evaluation of the effectiveness of the Ovation Alto Abdominal Stent Graft System when used in the treatment of subjects with abdominal aortic aneurysm (AAA).

Detailed Description

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A prospective clinical evaluation of the effectiveness of the Ovation Alto Abdominal Stent Graft System when used in the treatment of subjects with abdominal aortic aneurysm (AAA). The primary objective is to evaluate treatment success at 12 months with the Ovation Alto Abdominal Stent Graft system. The study will have up to 16 sites, and up to 75 patients based on attrition rates. The follow-up intervals will be at 1, 6, and 12 months following initial implant procedure.

Conditions

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Aortic Aneurysm, Abdominal

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Ovation Alto Abdominal Stent Graft System

Endovascular repair of AAA using the Ovation Alto Abdominal Stent Graft System.

Group Type OTHER

Ovation Alto Abdominal Stent Graft System

Intervention Type DEVICE

Repair of Abdominal Aortic Aneurysm with Ovation Alto Abdominal Stent Graft System

Interventions

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Ovation Alto Abdominal Stent Graft System

Repair of Abdominal Aortic Aneurysm with Ovation Alto Abdominal Stent Graft System

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Patient has adequate iliac/femoral access compatible with the required delivery systems.
2. Patient has non-aneurysmal proximal aortic neck.
3. Patient has non-aneurysmal distal iliac landing zone.

Exclusion Criteria

1. Patient has dissecting aneurysm.
2. Patient has acutely ruptured aneurysm.
3. Patient has need for emergent surgery.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Endologix

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sean Lyden, MD

Role: PRINCIPAL_INVESTIGATOR

The Cleveland Clinic

Locations

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Abrazo Arizona Heart Hospital

Phoenix, Arizona, United States

Site Status

VA San Diego

San Diego, California, United States

Site Status

Northwestern University

Chicago, Illinois, United States

Site Status

Carle Foundation Hospital

Urbana, Illinois, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

New Mexico Heart Institute

Albuquerque, New Mexico, United States

Site Status

University at Buffalo Clinical Translational Research Center/Kaleida Health/GVI/Buffalo General Medical Center

Buffalo, New York, United States

Site Status

Mission Hospital

Asheville, North Carolina, United States

Site Status

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

North Central Heart

Sioux Falls, South Dakota, United States

Site Status

Wellmont CVA Heart Institute

Kingsport, Tennessee, United States

Site Status

Baylor St. Luke's Medical Center

Houston, Texas, United States

Site Status

Swedish Heart and Vascular Research

Seattle, Washington, United States

Site Status

Countries

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United States

References

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Lyden SP, Metzger DC, Henao S, Noor S, Barleben A, Henretta JP, Kirksey L. One-year safety and effectiveness of the Alto abdominal stent graft in the ELEVATE IDE trial. J Vasc Surg. 2023 Feb;77(2):446-453.e3. doi: 10.1016/j.jvs.2022.08.016. Epub 2022 Aug 24.

Reference Type DERIVED
PMID: 36028158 (View on PubMed)

Provided Documents

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Document Type: Study Protocol, Statistical Analysis Plan, and Informed Consent Form

View Document

Related Links

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http://www.endologix.com

Endologix Website

Other Identifiers

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771-0013

Identifier Type: -

Identifier Source: org_study_id

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