Over and Under/Aneugraft Pericardium Covered Stent Long Term Follow up Registry

NCT ID: NCT01307553

Last Updated: 2011-03-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

75 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-09-30

Study Completion Date

2015-04-30

Brief Summary

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The purpose of this study is to track the clinical safety and effectiveness of the Pericardium Covered Stent in "real world" use.

Detailed Description

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This is a multi-center registry of 75 patients treated with the Over and Under/Aneugraft Pericardium Covered Stent (PCS) (IGTI, Israel). The registry will involve the collection of demographic, clinical, and angiographic data on the treated patient population, including in-hospital, 30 day, 6-month, 1 year, 2 years and 3 years clinical follow-up data.

Conditions

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Diseased Saphenous Vein Grafts Aneurysmal Coronary Arteries

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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PCS Group

Pericardium Covered Stent

Intervention Type DEVICE

Percutaneous implantation of pericardium covered stent

Interventions

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Pericardium Covered Stent

Percutaneous implantation of pericardium covered stent

Intervention Type DEVICE

Other Intervention Names

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Over and Under Aneugraft

Eligibility Criteria

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Inclusion Criteria

* Patient is older than 18 years
* Patient must be available for follow-up
* Patient must be fully informed, provided with the patient information sheet and sign the Informed Consent Form prior to the procedure.
* The lesion to be treated should be suitable for treatment with a PCS in that:

* A. A suitable length and diameter PCS should be available
* B. For SVG disease a single or multiple PCS may be used
* C. For native coronary artery aneurysms the operator should be confident that the aneurysm may be excluded by the implantation of a single PCS

Exclusion Criteria

* Significant co-morbidity precluding clinical follow-up.
* Pregnancy; pregnancy test negative in women with child bearing potential
* Acute ST-elevation myocardial infarction within the preceding 48 hours
* Previous stent implantation in the target vessel
* Left main coronary artery disease
* Contra-indication to dual anti-platelet therapy.
* Planned surgery which will lead to discontinuation of antiplatelet therapy
* Thrombocytopenia (\<100,000/mm3)
* Ejection fraction \<30%.
* Renal failure (creatinine \>180 µmol/L \[2 mg/dL\])
* Prior brachytherapy
* Recipient of heart transplant
* Acute infections
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ITGI Medical

INDUSTRY

Sponsor Role lead

Responsible Party

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ITGI Medical

Principal Investigators

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Asif Qasim

Role: PRINCIPAL_INVESTIGATOR

King's College Hospital NHS Trust

Morris Mosseri, MD

Role: PRINCIPAL_INVESTIGATOR

Sapir Health Center, Cfar Saba, Israel

Locations

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Sapir Health Center

Cfar Saba, , Israel

Site Status NOT_YET_RECRUITING

Kings College Hospital

London, , United Kingdom

Site Status RECRUITING

Countries

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Israel United Kingdom

Central Contacts

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Matthew Lewis, MD

Role: CONTACT

+972722200338

Shimon Lobel

Role: CONTACT

+972722200351

Facility Contacts

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Morris Mosseri, MD

Role: primary

Asif Qasim, MA PhD MRCP

Role: primary

References

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Siregar S, Hoseyni Guyomi S, van Herwerden LA. Covered stents in giant coronary artery aneurysm. Eur Heart J. 2010 Nov;31(22):2823. doi: 10.1093/eurheartj/ehq267. Epub 2010 Jul 30. No abstract available.

Reference Type BACKGROUND
PMID: 20675659 (View on PubMed)

Malkin C, Gunn J. A big cover-up. Heart. 2009 Aug;95(16):1354. doi: 10.1136/hrt.2009.171843. No abstract available.

Reference Type BACKGROUND
PMID: 19638513 (View on PubMed)

Wykrzykowska JJ, Gutierrez-Chico JL, van Geuns RJ. "Over-and-under" pericardial covered stent with paclitaxel balloon in a saphenous vein graft. Catheter Cardiovasc Interv. 2010 May 1;75(6):964-6. doi: 10.1002/ccd.22412.

Reference Type BACKGROUND
PMID: 20432403 (View on PubMed)

Tyczynski P, Kukreja N, van Geuns RJ, Wykrzykowska JJ, Sheppard MN, Di Mario C. Optical coherence tomography for the assessment of pericardium covered stents for the treatment of degenerated saphenous vein grafts. EuroIntervention. 2010 May;6(1):78-85.

Reference Type BACKGROUND
PMID: 20542801 (View on PubMed)

Jokhi PP, McKenzie DB, O'Kane P. Use of a novel pericardial covered stent to seal an iatrogenic coronary perforation. J Invasive Cardiol. 2009 Oct;21(10):E187-90.

Reference Type BACKGROUND
PMID: 19805849 (View on PubMed)

Hayat SA, Ghani S, More RS. Treatment of ruptured coronary aneurysm with a novel covered stent. Catheter Cardiovasc Interv. 2009 Aug 1;74(2):367-70. doi: 10.1002/ccd.21937.

Reference Type BACKGROUND
PMID: 19642186 (View on PubMed)

Colombo A, Almagor Y, Gaspar J, Vonderwalde C. The pericardium covered stent (PCS). EuroIntervention. 2009 Aug;5(3):394-9. doi: 10.4244/v5i3a61. No abstract available.

Reference Type BACKGROUND
PMID: 19736166 (View on PubMed)

Heper G, Barcin C, Iyisoy A, Tore HF. Treatment of an iatrogenic left internal mammary artery to pulmonary artery fistula with a bovine pericardium covered stent. Cardiovasc Intervent Radiol. 2006 Sep-Oct;29(5):879-82. doi: 10.1007/s00270-005-0149-2.

Reference Type BACKGROUND
PMID: 16736101 (View on PubMed)

Gaspar J, Martinez-Rios MA, Vonderwalde C, Rosas M, Ban-Hayashi E, Eidt-Lidt G, Kuri J. Pericardium-covered stent for septal myocardial ablation in hypertrophic obstructive cardiomyopathy. Catheter Cardiovasc Interv. 1999 May;47(1):73-9. doi: 10.1002/(SICI)1522-726X(199905)47:13.0.CO;2-Z.

Reference Type BACKGROUND
PMID: 10385166 (View on PubMed)

Gaspar J, Vonderwalde C, Hong MK, Eid-Lidt G, Almagor Y, Leon MB. [Stent coated with bovine pericardium: in vitro evaluation, in animals, and initial results in humans]. Arch Cardiol Mex. 2001 Oct-Dec;71(4):286-94. Spanish.

Reference Type BACKGROUND
PMID: 11806031 (View on PubMed)

Gaspar J, Vonderwalde C, Eid-Lidt G. Treatment of coronary artery aneurysms by percutaneous sealing with bovine-pericardium-covered stents. Int J Cardiovasc Intervent. 1999;2(4):241-246. doi: 10.1080/acc.2.4.241.246.

Reference Type BACKGROUND
PMID: 12623575 (View on PubMed)

Ferlini M, Russo F, Marinoni B, Repetto A, Canosi U, Ferrario M, Visconti LO, Bramucci E. Images in cardiology. Percutaneous coronary aneurysm obliteration using a novel pericardium-covered stent. J Am Coll Cardiol. 2010 Dec 14;56(25):2139. doi: 10.1016/j.jacc.2010.04.071. No abstract available.

Reference Type RESULT
PMID: 21144975 (View on PubMed)

Other Identifiers

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Sleeve III

Identifier Type: -

Identifier Source: org_study_id

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