Phase II Study of the Safety and Efficacy of the Relay Thoracic Stent-Graft

NCT ID: NCT00435942

Last Updated: 2018-01-16

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2017-05-15

Brief Summary

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The purpose of this study is to evaluate the safety and efficacy of the Relay thoracic stent-graft system to treat thoracic aortic aneurysms. Efficacy will be evaluated by the device-related adverse event rate of endovascular repair (via Relay Thoracic Stent-Graft) through 1-year. Safety will be evaluated by comparing major adverse events through 1-year in subjects treated with the Relay Thoracic Stent-Graft to those who underwent surgical repair. Long term follow-up is conducted through 5 years.

Detailed Description

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Conditions

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Thoracic Aortic Aneurysms and Penetrating Atherosclerotic Ulcers

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Endovascular Treatment arm to be implanted with Relay device

Group Type EXPERIMENTAL

Relay Thoracic Stent-Graft

Intervention Type DEVICE

implant

2

Surgical Control, underwent open repair

Group Type ACTIVE_COMPARATOR

Open Repair

Intervention Type PROCEDURE

Open surgery

Interventions

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Relay Thoracic Stent-Graft

implant

Intervention Type DEVICE

Open Repair

Open surgery

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Subjects with diagnosed descending thoracic aortic aneurysms or penetrating atherosclerotic ulcers
* Subjects who are at least 18 years of age
* Subjects whose anatomy can accommodate the Relay device
* Subjects who consent to participate
* Subjects who agree to comply with follow-up schedule

Exclusion Criteria

* Subjects with non-aneurysm lesions
* Subjects with less than 1 year life expectancy
* Subjects who are pregnant
* Subjects with medical conditions that would complicate the endovascular procedure or confound the results (e.g., Marfan's Syndrome, prior repair in the thoracic aorta, severe coronary artery disease, morbid obesity, etc.)
* Subjects participating in another investigational study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bolton Medical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mark Farber, MD

Role: PRINCIPAL_INVESTIGATOR

University of North Carolina

Locations

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Arizona Heart Hospital

Phoenix, Arizona, United States

Site Status

University of Arizona

Tucson, Arizona, United States

Site Status

University of California-San Francisco

San Francisco, California, United States

Site Status

Washington Hospital Center

Washington D.C., District of Columbia, United States

Site Status

University of Florida

Gainesville, Florida, United States

Site Status

University of Miami

Miami, Florida, United States

Site Status

Baptist Cardiac and Vascular Institute

Miami, Florida, United States

Site Status

Emory University

Atlanta, Georgia, United States

Site Status

Rockford Memorial Hospital

Rockford, Illinois, United States

Site Status

Clarian Cardiovascular

Indianapolis, Indiana, United States

Site Status

Indiana Heart Hospial

Indianapolis, Indiana, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

University of Michigan

Ann Arbor, Michigan, United States

Site Status

The Mayo Clinic

Rochester, Minnesota, United States

Site Status

Albany Medical Center

Albany, New York, United States

Site Status

New York Presbyterian Hospital --Columbia/Cornell University

New York, New York, United States

Site Status

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States

Site Status

East Carolina University

Greenville, North Carolina, United States

Site Status

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

Ohio State University

Columbus, Ohio, United States

Site Status

Hospital of the University of Pennsylvania/Penn Presbyterian

Philadelphia, Pennsylvania, United States

Site Status

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status

Methodist Hospital

Houston, Texas, United States

Site Status

INOVA Fairfax Hospital

Falls Church, Virginia, United States

Site Status

Sentara Heart Hospital

Norfolk, Virginia, United States

Site Status

University of Washington

Seattle, Washington, United States

Site Status

Aurora St. Luke's Hospital

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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IP-0004-06

Identifier Type: -

Identifier Source: org_study_id

NCT00998491

Identifier Type: -

Identifier Source: nct_alias

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