Evaluation of the GORE TAG Thoracic Endoprosthesis in the Treatment of Aneurysms

NCT ID: NCT00590759

Last Updated: 2014-08-07

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-08-31

Study Completion Date

2013-04-30

Brief Summary

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The purpose of this post-approval study is to evaluate the long-term performance of the GORE TAG® Thoracic Endoprosthesis (TAG device) in the primary treatment of descending thoracic aortic (DTA) aneurysms

Detailed Description

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Conditions

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Aortic Aneurysm, Thoracic

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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GORE TAG® Thoracic Endoprosthesis

Group Type OTHER

GORE TAG® Thoracic Endoprosthesis

Intervention Type DEVICE

implant

Interventions

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GORE TAG® Thoracic Endoprosthesis

implant

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Descending thoracic aortic aneurysm deemed to warrant surgical repair:

1. Fusiform aneurysm greater than or equal to 2 times diameter of normal adjacent aorta
2. Saccular aneurysm
2. Anatomy meets GORE TAG Thoracic Endoprosthesis specification criteria as indicated in the Instructions for Use (Appendix A)
3. Minimum 2 cm non-aneurysmal segment proximal and distal to the aneurysm

• \<60 degree angle in the aortic arch may require additional length of non-aneurysmal segment if the arch is included in the treatment segment
4. Life expectancy \> 2 years
5. Surgical Candidate

* ASA Class I, II, III, or IV
* NYHA Class I, II, III or no heart disease
6. Male or infertile female
7. Minimum 21 years of age
8. Able to comply with protocol requirements
9. Signed Informed Consent Form

Exclusion Criteria

1. 4 mm aortic taper and inability to use devices of different diameters, to compensate for the taper, in the treatment area of the aorta
2. Significant thrombus at the proximal or distal implantation zones
3. Mycotic aneurysm
4. Hemodynamically unstable aneurysm rupture (non-contained aneurysm rupture)
5. Acute or chronic aortic dissection
6. Planned occlusion of the left carotid or celiac arteries
7. "Planned" concomitant surgical procedure (other than left subclavian transposition) or previous major surgery within 30 days
8. Myocardial infarction or cerebral vascular accident within 6 weeks
9. Severe respiratory insufficiency sufficient that precludes open thoracotomy
10. Renal insufficiency (Creatinine \> 2.0 mg/dL) with or without dialysis
11. Degenerative connective tissue disease, e.g., Marfan or Ehler-Danlos Syndrome
12. Participation in another investigational device or drug study within 1 year
13. Documented history of drug abuse within 6 months
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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W.L.Gore & Associates

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mark Morasch, M.D.

Role: PRINCIPAL_INVESTIGATOR

St. Vincent's Healthcare, Billings MT

Locations

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Phoenix, Arizona, United States

Site Status

Los Angeles, California, United States

Site Status

San Francisco, California, United States

Site Status

Greeley, Colorado, United States

Site Status

Gainesville, Florida, United States

Site Status

Miami, Florida, United States

Site Status

Chicago, Illinois, United States

Site Status

Peoria, Illinois, United States

Site Status

Kansas City, Kansas, United States

Site Status

New Orleans, Louisiana, United States

Site Status

Boston, Massachusetts, United States

Site Status

St Louis, Missouri, United States

Site Status

Albany, New York, United States

Site Status

New York, New York, United States

Site Status

Durham, North Carolina, United States

Site Status

Philadelphia, Pennsylvania, United States

Site Status

Pittsburgh, Pennsylvania, United States

Site Status

Memphis, Tennessee, United States

Site Status

Nashville, Tennessee, United States

Site Status

Dallas, Texas, United States

Site Status

Temple, Texas, United States

Site Status

Salt Lake City, Utah, United States

Site Status

Charlottesville, Virginia, United States

Site Status

Seattle, Washington, United States

Site Status

Vancouver, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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TAG 05-02

Identifier Type: -

Identifier Source: org_study_id

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