Exercise Training Improves Coronary Endothelial Dysfunction in Diabetes Mellitus Type 2 and Coronary Artery Disease
NCT ID: NCT00693537
Last Updated: 2019-08-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
INTERVENTIONAL
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
Study Groups
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A
4 weeks in-hospital exercise training (6x15 min bicycle/day, 5 days/week) followed by a 5 months ambulatory exercise program (30 min ergometer/day, 5 days/week, plus 1h group exercise/week)
Exercise training
4 weeks in-hospital exercise training (6x15 min bicycle/day, 5 days/week) followed by a 5 months ambulatory exercise program (30 min ergometer/day, 5 days/week, plus 1h group exercise/week)
B
Control
No interventions assigned to this group
Interventions
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Exercise training
4 weeks in-hospital exercise training (6x15 min bicycle/day, 5 days/week) followed by a 5 months ambulatory exercise program (30 min ergometer/day, 5 days/week, plus 1h group exercise/week)
Eligibility Criteria
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Inclusion Criteria
* preserved left ventricular function (left ventricular ejection fraction ≥ 50%)
* a physical work capacity ≥ 50 W
* at least one significant coronary stenosis \> 50%, whereas either the left anterior descending (LAD) or circumflex artery (RCX) has to be free from disease or stenoses ≤ 25% for the assessment of intracoronary flow measurements
Exclusion Criteria
* untreated hypertension (systolic blood pressure \> 160 mm Hg or a diastolic blood pressure of \> 90 mm Hg)
* cigarette smoking during the previous six months
* LDL-cholesterol \> 4.3 mmol/l
* ventricular tachyarrhythmias
* chronic obstructive pulmonary disease
* severe renal or hepatic dysfunction
* valvular heart disease
* myocardial infarction within the previous 4 weeks
50 Years
80 Years
ALL
No
Sponsors
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Paracelsus Medical University
OTHER
Responsible Party
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Prof. Josef Niebauer M.D., Ph.D., MBA
Director of Institute
Locations
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University Institute of Sports Medicine, Prevention and Rehabilitation
Salzburg, , Austria
Countries
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Other Identifiers
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UISM-2-2008
Identifier Type: -
Identifier Source: org_study_id
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