Morphometric Analysis of Orbital Structures in Graves´ Orbitopathy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-07-31

Study Completion Date

2013-11-30

Brief Summary

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The purpose of this protocol is to study orbital structures in Graves´ Disease using multidetector computed tomography and color doppler imaging.

Some changes in orbital structures detected by imaging exams could predict severity of the ocular Graves´disease. Thus the study could be useful in improve medical management of patients with Graves´ Disease.

Detailed Description

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Morphometric analysis of orbital structures in Graves´ Orbitopathy using multidetector computed tomography scan and color doppler imaging:

Patients with Graves´ orbitopathy are evaluated by a complete ophthalmic examination.A prospective study with Multidetector CT scan and Color Doppler of these patients are made to develop parameters capable to predict Dysthyroid Optic Neuropathy (DON).

Conditions

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Dysthyroid Orbitopathy

Keywords

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Dysthyroid Optic Neuropathy multidetector computed tomography color doppler Grave´s Orbitopathy Grave´s Disease morphometric analysis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1Patients with Graves´orbitophathy.

Patients with Graves´orbitophathy.

No interventions assigned to this group

2 Patients with detected DON

Patients with Graves´orbitophaty and detected dysthyroid optic neuropathy (DON)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Graves´Orbitopathy diagnosed based on previously reported criteria
* Age above 20 years
* Good cooperation for performing Visual Field test
* Spherical refraction within ± 5 D and cylinder correction within ± 3 D

Exclusion Criteria

* Graves´Orbitopathy not diagnosed

Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Allan Christian Pieroni Goncalves

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mario L Monteiro, MD, PhD

Role: STUDY_CHAIR

University of Sao Paulo - School of Medicine

Locations

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General Hospital - University of Sao Paulo - School of Medicine

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

References

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Goncalves AC, Silva LN, Gebrim EM, Monteiro ML. Quantification of orbital apex crowding for screening of dysthyroid optic neuropathy using multidetector CT. AJNR Am J Neuroradiol. 2012 Sep;33(8):1602-7. doi: 10.3174/ajnr.A3029. Epub 2012 Mar 22.

Reference Type DERIVED

PMID: 22442048 (View on PubMed)

Other Identifiers

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1152/05

Identifier Type: -

Identifier Source: org_study_id