Ocular Pulse Amplitude And Choroidal Laser Doppler Flowmetry

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-01-31

Study Completion Date

2011-08-31

Brief Summary

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This study intends to investigate the relationship between choroidal blood flow and ocular pulse amplitude (OPA).

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Detailed Description

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One eye is randomly selected in 18 healthy subjects. OPA is assessed with Dynamic Contour Tonometry. Submacular choroidal blood flow is measured with Laser Doppler Flowmetry. During both examinations the systemic blood pressure is continuously recorded with Finometer. An average systolic and diastolic LDF parameter flow during 30 seconds are determined and the pulsatility index is calculated according to the formula (LDFsys-LDFdia)/LDFdia. An association of OPA with the LDF pulsatility index, systemic blood pressure values and mean intraocular pressure will be analysed.

Conditions

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Healthy

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Healthy subjects should present no history of ocular diseases, of current topical medication, or of drug or alcohol abuse. Furthermore, a best corrected visual acuity above 20/25 in both eyes, lack of pathological findings upon a slit-lamp examination and dilated direct fundoscopy, and an IOP \< 21 mmHg in both eyes will be required.

Exclusion Criteria

* History of chronic or recurrent severe inflammatory eye disease such as scleritis or uveitis.
* History of ocular trauma or intraocular surgery. History of infection or inflammation within the past 3 months.
* History and clinical evidence for other retinal disease such as age-related degeneration, or diabetic retinopathy.

Minimum Eligible Age

45 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes