Retinal Microvascularization and Cardiovascular Disease
NCT ID: NCT03551717
Last Updated: 2020-05-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
155 participants
OBSERVATIONAL
2018-03-14
2019-04-19
Brief Summary
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The arteries and veins of the retina are, like the large vessels of the human body (aorta, coronary, cerebral arteries), exposed to the complications of hypertension, diabetes, obesity, dyslipidemia (abnormal blood lipid profile) or tobacco. Several studies have shown that changes in retinal vessels (microvascularization) generally occur several years before damage to large peripheral vessels (macrovascularization). The study of the vessels of the retina is now possible thanks to simple and non-invasive examinations of photographs (not creating any lesion). They allow a painless evaluation of the vessels in the retina.
Ultimately, if this study is conclusive, the patient's cardiovascular risk could be evaluated simply by analysis of the vessels of the retina.
The study is being conducted in the ophthalmology and cardiology departments of Dijon University Hospital. In total, the investigators wish to include approximately 510 patients who present cardiovascular risk factors (255 low risk patients recruited in the ophthalmology department and 255 high risk patients hospitalized in the cardiology department).
All patients participating in the study will be asked to visit the ophthalmology department for a complete examination of the retina.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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High cardiovascular risk patients
Adult patients hospitalized in the Cardiology Department of the University Hospital of Dijon Burgundy for acute coronary syndrome, patients between D1 and D5 of acute coronary syndrome, who can be moved for an ophthalmology consultation where the retinal imaging is done (heart monitoring in the presence of an experienced cardiologist if necessary)
Optical Coherence Tomography angiography
At the inclusion visit for all patients and at M3 only for 50 patients.
Fundus
At the inclusion visit for all patients and at M3 only for 50 patients.
cardiac ultrasound scan
Only for 50 patients, 3 months after the initial cardiovascular event
Low cardiovascular risk patients
Adult patients recruited in the Ophthalmology Department of the University Hospital of Dijon Burgundy following a standard consultation for cataract surgery.
The age balance of the patients included in the two groups will be checked regularly.
Optical Coherence Tomography angiography
At the inclusion visit for all patients and at M3 only for 50 patients.
Fundus
At the inclusion visit for all patients and at M3 only for 50 patients.
Interventions
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Optical Coherence Tomography angiography
At the inclusion visit for all patients and at M3 only for 50 patients.
Fundus
At the inclusion visit for all patients and at M3 only for 50 patients.
cardiac ultrasound scan
Only for 50 patients, 3 months after the initial cardiovascular event
Eligibility Criteria
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Inclusion Criteria
* High cardiovascular risk group: Adult patients hospitalized in the Cardiology Department of the University Hospital of Dijon Burgundy for acute coronary syndrome, patients between D1 and D5 of acute coronary syndrome, who can be moved for an ophthalmology consultation where the retinal imaging is done (heart monitoring in the presence of an experienced cardiologist if necessary)
* Low cardiovascular risk group: Adult patients over 40 years of age recruited in the Ophthalmology Department of the University Hospital of Dijon Burgundy following a standard consultation for cataract surgery, ocular surface pathologies and optical correction.
Exclusion Criteria
* Patient refusal
* Minor patient
* Protected patient
* Ophthalmological history (macular vascular or degenerative disorders)
18 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire Dijon
OTHER
Responsible Party
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Locations
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Chu Dijon Bourogne
Dijon, , France
Countries
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Other Identifiers
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MEILLON AOI 2017
Identifier Type: -
Identifier Source: org_study_id
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