Retina Microvascularisation and Cardiovascular Heart Disease Prediction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-09-30

Study Completion Date

2013-10-31

Brief Summary

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Earlier studies have found that retinal photography could be very useful for evaluating the condition of microcirculation and the risk of cardiovascular diseases in patients. The architectural changes in retinal vascularisation strongly correlates with macrovascular remodeling. Also, recent founding suggests a possible close anatomical parallel between both the macrovascular and the microvascular blood.

Our objectives are to assess (1) in which age and sex subgroups, if any, retinal vascular alteration in arterioles and venules can be predictive for cardiovascular morbidity and mortality; and (2) whether variations in arteriolar or venular caliber will predict better cardiovascular pathogenesis in normal and patient population. If the association between the diameter of the retinal vessels and the risks of cardiovascular disease is verified during this study, the impact on prevention would be enormous. The retinal microvascular change could become a powerful biomarker in the early detection of the cardiovascular pathogenesis and death risk

Detailed Description

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Conditions

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Cardiovascular Disease

Keywords

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Retinal Microvascularisation Fundus mfERGs CHF Cardiovascular Disease Coronarography Macrovascularisation The objectives are to assess if if any retinal vascular disorder in arterioles and venules can be predictive for cardiovascular morbidity and mortality

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Age between 50 to 70 years old (male/female)
* indication of coronarography within the last 3 month preceding the enrollment
* Patients with history of stroke, heart failure or arteriosclerosis.
* At least one of the following risk factors for cardiovascular complication:

* Hypertension
* Coronary heart disease (CHD)
* Diabetes
* Structural heart disease
* Dyslipidemia
* Obesity

Exclusion Criteria

* Patients with a permanent pacemaker or ICD
* Nephrosis or chronic renal failure
* The study interferes with therapeutic or diagnostic procedures
* Patients with inability to consent or comply with follow up requirements
* Patients with glaucoma
* Patients with any retina degeneration disease vascular age-related macular degeneration or any -retina degeneration disease
* Patients who are pregnant

Minimum Eligible Age

50 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Bernard Thibault

Cardiologist - Electrophysiologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bernard Thibault, MD

Role: PRINCIPAL_INVESTIGATOR

Montreal Heart Institute

Locations

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Montreal Heart Institute, 5000 Belanger Street

Montreal, Quebec, Canada

Site Status

Countries

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Canada

Other Identifiers

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ICM 08-1050

Identifier Type: -

Identifier Source: org_study_id