A Multicenter, Randomized, Parallel Group, Double-Blind, Placebo Controlled, Flexible Dose Escalation Study To Evaluate Sexual And Relationship Satisfaction In The Female Partner Of Men With Erectile Dysfunction Treated With Sildenafil Citrate

NCT ID: NCT00644631

Last Updated: 2021-02-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-06-30

Study Completion Date

2004-04-30

Brief Summary

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To compare the effects of sildenafil versus placebo on the female partner's sexual satisfaction as assessed by Question 3 of Female Partner of Erectile Dysfunction (ED) Subject Questionnaire (FePEDS-Q): "Over the past 4 weeks, when you had sexual intercourse, how often was it satisfactory for you?" For ED subjects, determine difference in the Erectile Function domain of International Index of Erectile Function (IIEF) between sildenafil citrate and placebo at end of the treatment phase and determine the overall relationship between improved erectile function and increased ED subject and female partner satisfaction.

Detailed Description

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Conditions

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Erectile Dysfunction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Arm 1

Group Type ACTIVE_COMPARATOR

sildenafil

Intervention Type DRUG

sildenafil 50 mg (initial dose) tablet by mouth 30 to 60 minutes prior to sexual activity for 12 weeks; depending upon safety, efficacy and tolerability, the dose could be increased to 100 mg or reduced to 25 mg, if necessary.

Arm 2

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

placebo tablet by mouth 30 to 60 minutes prior to sexual activity for 12 weeks

Interventions

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sildenafil

sildenafil 50 mg (initial dose) tablet by mouth 30 to 60 minutes prior to sexual activity for 12 weeks; depending upon safety, efficacy and tolerability, the dose could be increased to 100 mg or reduced to 25 mg, if necessary.

Intervention Type DRUG

placebo

placebo tablet by mouth 30 to 60 minutes prior to sexual activity for 12 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* The male patient must have had a documented clinical diagnosis of erectile dysfunction (ED) confirmed by a Sexual Health Inventory-Male (SHI-M) score of less than or equal to 21
* a stable female partner at least 21 years of age for at least 6 months prior to screening
* the couple must have been married or living together at the time of screening.
* The female partner must have answered "no intercourse," "sometimes," "a few times" or "almost never" on Question 3 of the Female Partner of ED Subject Questionnaire (FePEDS-Q)

Exclusion Criteria

* The male patient must not have had resting sitting and/or standing hypotension (BP \< 90/50mmHg) or hypertension (BP \> 170/110mmHg), or significant cardiovascular disease in the last 3 months, including cardiac failure, myocardial infarction, unstable angina, stroke, transient ischemic attack (TIA), symptomatic or clinically significant cardiac arrhythmias.
* Female partners must not have had significant dyspareunia or lifelong significant sexual dysfunction based on female partner's medical and sexual history at screening.
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Huntsville, Alabama, United States

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Little Rock, Arkansas, United States

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Beverly Hills, California, United States

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Laguna Woods, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Palo Alto, California, United States

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Torrance, California, United States

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Aurora, Colorado, United States

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Waterbury, Connecticut, United States

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Ocala, Florida, United States

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Peoria, Illinois, United States

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Jeffersonville, Indiana, United States

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Des Moines, Iowa, United States

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Overland Park, Kansas, United States

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Baltimore, Maryland, United States

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Peabody, Massachusetts, United States

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St Louis, Missouri, United States

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Garden City, New York, United States

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New York, New York, United States

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New York, New York, United States

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Poughkeepsie, New York, United States

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Durham, North Carolina, United States

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Beachwood, Ohio, United States

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Newtown, Pennsylvania, United States

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Knoxville, Tennessee, United States

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Dallas, Texas, United States

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San Antonio, Texas, United States

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Lacey, Washington, United States

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Seattle, Washington, United States

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Spokane, Washington, United States

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Countries

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United States

Related Links

Other Identifiers

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A1481177

Identifier Type: -

Identifier Source: org_study_id

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