Treatment of Erectile Dysfunction - Long Term Safety and Efficacy

NCT ID: NCT01065012

Last Updated: 2015-04-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1027 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2011-02-28

Brief Summary

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Open-Label Phase 3 study to evaluate the long-term safety and efficacy of udenafil, an orally administered selective inhibitor of PDE-5 for the treatment of subjects with erectile dysfunction (ED).

Detailed Description

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Patients completing the double-blind phase will be entered into Study 01409 at the intermediate dose. Up and down dose adjustments will be allowed.

Conditions

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Erectile Dysfunction

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Udenafil 50 mg

50 mg Udenafil

Group Type EXPERIMENTAL

Udenafil 50 mg

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Placebo Matching 100 mg Udenafil

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Placebo Matching 150 mg Udenafil

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Udenafil 100 mg

100 mg Udenafil

Group Type EXPERIMENTAL

Udenafil 100 mg

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Placebo Matching 50 mg Udenafil

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Placebo Matching 150 mg Udenafil

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Udenafil 150 mg

150 mg Udenafil

Group Type EXPERIMENTAL

Udenafil 150 mg

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Placebo Matching 50 mg Udenafil

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Placebo Matching 100 mg Udenafil

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Placebo

Placebo Tablets matching Udenafil tablets

Group Type PLACEBO_COMPARATOR

Placebo Matching 50 mg Udenafil

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Placebo Matching 100 mg Udenafil

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Placebo Matching 150 mg Udenafil

Intervention Type DRUG

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Interventions

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Udenafil 50 mg

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Intervention Type DRUG

Udenafil 100 mg

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Intervention Type DRUG

Udenafil 150 mg

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Intervention Type DRUG

Placebo Matching 50 mg Udenafil

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Intervention Type DRUG

Placebo Matching 100 mg Udenafil

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Intervention Type DRUG

Placebo Matching 150 mg Udenafil

Tablets via oral administration before an attempt at sexual intercourse. All subjects started at 100 mg and titrated up to 150 mg or down to 50 mg per Investigator and subject.

Intervention Type DRUG

Other Intervention Names

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WC3043 WC3043 WC3043 Placebo 50 mg Placebo 100 mg Placebo 150 mg

Eligibility Criteria

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Inclusion Criteria

* Subject has completed Study PR-01209 or PR-01309
* Continues in a stable monogamous relationship with a consenting female partner who is at least 19 years of age.
* Partner is not pregnant or lactating

Exclusion Criteria

* Symptomatic coronary artery disease, myocardial infarction or cardiac surgical procedure.
* Cardiac arrhythmias requiring antiarrhythmic treatment
* Symptomatic congestive heart failure
* Taking nitrate medication in any form
* Uncontrolled diabetes (HbA1c ≥ 13%)
* Hypersensitivity to phosphodiesterase type 5 (PDE-5) inhibitors
Minimum Eligible Age

19 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Warner Chilcott

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Herman Ellman, MD

Role: STUDY_DIRECTOR

Warner Chilcott

Locations

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Warner Chilcott Investigational Site

Birmingham, Alabama, United States

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Homewood, Alabama, United States

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Huntsville, Alabama, United States

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Mesa, Arizona, United States

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Phoenix, Arizona, United States

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Tempe, Arizona, United States

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Tucson, Arizona, United States

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Chino, California, United States

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Laguna Hills, California, United States

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Newport Beach, California, United States

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San Diego, California, United States

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Tarzana, California, United States

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Torrance, California, United States

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Denver, Colorado, United States

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Englewood, Colorado, United States

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Middlebury, Connecticut, United States

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Milford, Connecticut, United States

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New Britain, Connecticut, United States

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Waterbury, Connecticut, United States

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Aventura, Florida, United States

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Clearwater, Florida, United States

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Daytona Beach, Florida, United States

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DeLand, Florida, United States

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Miami, Florida, United States

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Ocala, Florida, United States

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Ocala, Florida, United States

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Tampa, Florida, United States

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Columbus, Georgia, United States

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Dawsonville, Georgia, United States

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Sandy Springs, Georgia, United States

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Melrose Park, Illinois, United States

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Fort Wayne, Indiana, United States

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Greenwood, Indiana, United States

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Jeffersonville, Indiana, United States

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West Des Moines, Iowa, United States

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Elkridge, Maryland, United States

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Omaha, Nebraska, United States

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Las Vegas, Nevada, United States

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Lawrenceville, New Jersey, United States

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Bay Shore, New York, United States

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Garden City, New York, United States

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Kingston, New York, United States

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New York, New York, United States

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Poughkeepsie, New York, United States

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Rochester, New York, United States

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Williamsville, New York, United States

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Cary, North Carolina, United States

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Concord, North Carolina, United States

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Harrisburg, North Carolina, United States

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Raleigh, North Carolina, United States

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Raleigh, North Carolina, United States

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Salisbury, North Carolina, United States

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Wilmington, North Carolina, United States

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Wilmington, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Bala-Cynwyd, Pennsylvania, United States

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Jenkintown, Pennsylvania, United States

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Lancaster, Pennsylvania, United States

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Greer, South Carolina, United States

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Mt. Pleasant, South Carolina, United States

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Myrtle Beach, South Carolina, United States

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Arlington, Texas, United States

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San Antonio, Texas, United States

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Sugar Land, Texas, United States

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Salt Lake City, Utah, United States

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Norfolk, Virginia, United States

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Richmond, Virginia, United States

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Mountlake Terrace, Washington, United States

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Spokane, Washington, United States

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Spokane, Washington, United States

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Countries

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United States

Other Identifiers

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PR-01409

Identifier Type: -

Identifier Source: org_study_id

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