Levitra (Vardenafil, BAY38-9456) Partner Satisfaction Study II

NCT ID: NCT00377793

Last Updated: 2014-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

352 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-07-31

Study Completion Date

2007-08-31

Brief Summary

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This trial is to provide additional important information on the impact of the treatment of the man its ED with vardenafil on partnership. This study is being run at up to 50 study centers in Europe and South Africa to evaluate the use of vardenafil in adult men with erectile dysfunction (often called impotence), and their female partner's sexual quality of life. Many men experience occasional erectile problems during their lives. However, when this becomes a continued problem, it can affect both the man and his female partner. The causes of erectile dysfunction are varied and may be due to physiological or emotional reasons. This study is designed to 1) study the effectiveness and safety of vardenafil, and 2) show whether treating a man its erectile dysfunction with vardenafil will improve his female partner its sexual quality of life. The second part (week 12) of the study (Educational program) a subgroup of subjects/couples, approximately 50% of the randomized subjects, will receive an educational program concerning ED in the from of a DVD.

Detailed Description

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Conditions

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Sexual Dysfunction Male Erectile Dysfunction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Arm 1

Group Type EXPERIMENTAL

Levitra (Vardenafil, BAY38-9456)

Intervention Type DRUG

Arm 2

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Interventions

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Levitra (Vardenafil, BAY38-9456)

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Males 18 to 64 years
* Males with ED for more than six months, according to the NIH Consensus Statement (inability to attain and/or maintain penile erection sufficient for satisfactory sexual performance)
* Stable heterosexual relationship for more than 6 months
* The subject must make at least four attempts at sexual intercourse
* Females 18 years, and older
* Stable, heterosexual relationship for more than 6 months with male ED subject
* Documented, dated, written Informed Consent
* Motivated to support treatment for male partner's ED
* Absence of significant sexual dysfunction as assessed by the total score on the FSFI16 \> 23.55

Exclusion Criteria

* Any unstable medical condition or substance abuse disorder that, in the opinion of the Investigator, is likely to affect the patient's ability to complete the study or precludes the patient's participation in the study
* Subjects who are taking nitrates or nitric oxide donors
* Subjects who are taking the following inhibitors of cytochrome P 450 CYP 3A4: very potent HIV protease inhibitors (ritonavir, indinavir), the anti-mycotic agents traconazole and ketoconazole (topical forms are allowed) or erythromycin
* Known hypersensitivity to vardenafil
* Presence of significant penile anatomical abnormalities (e.g. penile fibrosis or Peyronie's disease)
* History of retinitis pigmentosa
* Unstable angina pectoris
* Severe chronic or acute liver disease
* Premature ejaculator (defined as IELT \< 2 minutes)
* Subjects who were taking alpha blockers
* Presence of sexual dysfunction as assessed by the FSFI16 \< 23.55
* Any unstable medical condition or substance abuse disorder that, in the opinion of the Investigator, is likely to affect the partner's ability to complete the study or precludes the partner's participation in the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

64 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Bayer

INDUSTRY

Sponsor Role lead

Responsible Party

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Bayer Schering Pharma AG

Principal Investigators

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Bayer Study Director

Role: STUDY_DIRECTOR

Bayer

Locations

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Bruxelles - Brussel, , Belgium

Site Status

Genk, , Belgium

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Leuven, , Belgium

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Liège, , Belgium

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Roeselare, , Belgium

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La Rochelle, , France

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Lille, , France

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Lyon, , France

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Marseille, , France

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Marseille, , France

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Mont-de-Marsan, , France

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Paris, , France

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Toulouse, , France

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Hamburg, Hamburg / 287, Germany

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Hamburg, Hamburg / 287, Germany

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Hamburg, Hamburg / 287, Germany

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Hanover, Niedersachsen / 291, Germany

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Brühl, Nordrhein-Westfalen / 325, Germany

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Mülheim, Nordrhein-Westfalen / 481, Germany

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Wuppertal, Nordrhein-Westfalen / 616, Germany

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Bautzen, Sachsen / 313, Germany

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Dresden, Sachsen / 313, Germany

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Leipzig, Sachsen / 313, Germany

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Leisnig, Sachsen / 313, Germany

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Meißen, Sachsen / 313, Germany

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Wahlstedt, Schleswig-Holstein / 306, Germany

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Bergamo, , Italy

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Florence, , Italy

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Milan, , Italy

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Napoli, , Italy

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Roma, , Italy

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Arnhem, , Netherlands

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Deventer, , Netherlands

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Enschede, , Netherlands

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Nijverdal, , Netherlands

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Bloemfontein, Free State, South Africa

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Johannesburg, Gauteng, South Africa

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Durban, KwaZulu-Natal, South Africa

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Durban, KwaZulu-Natal, South Africa

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Newcastle, KwaZulu-Natal, South Africa

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Alicante, Alicante, Spain

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Barcelona, Barcelona, Spain

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La Roca del Vallès, Barcelona, Spain

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Barcelona, Catalonia, Spain

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Vigo, Pontevedra, Spain

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San Cristóbal de La Laguna, Tenerife, Spain

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Valencia, Valencia, Spain

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Countries

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Belgium France Germany Italy Netherlands South Africa Spain

Related Links

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http://www.clinicaltrialsregister.eu/

Click here to find information about studies related to Bayer Healthcare products conducted in Europe

Other Identifiers

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EudraCT 2006-001228-37

Identifier Type: -

Identifier Source: secondary_id

12146

Identifier Type: -

Identifier Source: org_study_id