Assess the Effect of Daily Treatment of Vardenafil 20mg or Sildenafil 100mg and Placebo on Sperm Function

NCT ID: NCT00655590

Last Updated: 2014-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-01-31

Study Completion Date

2006-06-30

Brief Summary

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Assess the effect of daily treatment of vardenafil 20mg or sildenafil 100mg and placebo on sperm function

Detailed Description

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Conditions

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Erectile Dysfunction

Keywords

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Erectile Dysfunction Sildenafil Vardenafil Spermatogenesis Sperm concentration Sperm count Morphology Motility Reproductive hormonal

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Arm 1

Group Type EXPERIMENTAL

Levitra (Vardenafil, BAY38-9456)

Intervention Type DRUG

20 mg daily dosing

Arm 2

Group Type ACTIVE_COMPARATOR

Sildenafil

Intervention Type DRUG

100 mg daily dosing

Arm 3

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Matching placebos

Interventions

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Levitra (Vardenafil, BAY38-9456)

20 mg daily dosing

Intervention Type DRUG

Sildenafil

100 mg daily dosing

Intervention Type DRUG

Placebo

Matching placebos

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy male subjects or men with ED aged 25 - 64
* Baseline sperm conc. of \> 20 mio / ml- Normal World Health Organization A+B+C sperm mortality \> 50%- Normal sperm morphology (WHO, 1992 manual criteria) \> 30% and - 1.0 mL ejaculate volume at each of the 3 analyses during the screening phase.

Exclusion Criteria

* Presence of any psychological or physiological abnormalities that in the opinion of the Investigator would significantly impair sexual performance or ability to provide semen samples according to the protocol- Spinal cord injury
* History of surgical prostatectomy
Minimum Eligible Age

25 Years

Maximum Eligible Age

64 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Bayer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bayer Study Director

Role: STUDY_DIRECTOR

Bayer

Locations

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Phoenix, Arizona, United States

Site Status

Tempe, Arizona, United States

Site Status

Beverly Hills, California, United States

Site Status

La Mesa, California, United States

Site Status

Laguna Hills, California, United States

Site Status

San Diego, California, United States

Site Status

Torrance, California, United States

Site Status

Van Nuys, California, United States

Site Status

Waterbury, Connecticut, United States

Site Status

Aventura, Florida, United States

Site Status

New Orleans, Louisiana, United States

Site Status

Ann Arbor, Michigan, United States

Site Status

Minneapolis, Minnesota, United States

Site Status

Rochester, Minnesota, United States

Site Status

Great Neck, New York, United States

Site Status

New York, New York, United States

Site Status

Cincinnati, Ohio, United States

Site Status

San Antonio, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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11520

Identifier Type: -

Identifier Source: org_study_id