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Role of Pancreatic Triglyceride Content in Beta-cell Function

NCT ID: NCT00602953

Last Updated: 2017-12-26

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

101 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-09-30

Study Completion Date

2012-08-31

Brief Summary

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The study evaluates if fat accumulates in the pancreas in individuals at risk of developing obesity-related diabetes. It also evaluates if the amount of fat in the pancreas can predict the residual functional capacity of the pancreas (insulin secretion).

Detailed Description

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Conditions

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Obesity Type 2 Diabetes

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Healthy volunteers

Normal weight and normal glucose tolerance.

No intervention planned.

Intervention Type OTHER

This is a cross-sectional observational study, no intervention is planned.

Pre-diabetes

Impaired fasting glucose of impaired glucose tolerance.

No intervention planned.

Intervention Type OTHER

This is a cross-sectional observational study, no intervention is planned.

Overweight

Overweight or obese volunteers, but with normal fasting and postprandial glucose levels.

No intervention planned.

Intervention Type OTHER

This is a cross-sectional observational study, no intervention is planned.

Type 2 diabetes

Patients with type 2 diabetes.

No intervention planned.

Intervention Type OTHER

This is a cross-sectional observational study, no intervention is planned.

Type 1 diabetes

Patients with type 1 diabetes.

No intervention planned.

Intervention Type OTHER

This is a cross-sectional observational study, no intervention is planned.

Interventions

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No intervention planned.

This is a cross-sectional observational study, no intervention is planned.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* adults without prior history of pancreatic disease (other than diabetes)

Exclusion Criteria

* use of unapproved medications
* contraindications to the MRI procedure
* contraindications to frequent blood draws
* pregnancy
* use of more than 2 alcoholic drinks/day
Minimum Eligible Age

21 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

University of Texas Southwestern Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Ildiko Lingvay

MD, MPH, MSCS

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ildiko Lingvay, MD, MPH, MSCS

Role: PRINCIPAL_INVESTIGATOR

UT Southwestern Medical Center

Locations

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UT Southwestern Medical Center

Dallas, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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1K23RR02447001

Identifier Type: -

Identifier Source: secondary_id

042007-021

Identifier Type: -

Identifier Source: org_study_id