Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial
NCT ID: NCT00560664
Last Updated: 2025-12-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
58 participants
INTERVENTIONAL
2007-04-30
2013-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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1
Autologous chondrocytes transplantation
Autologous chondrocytes transplantation
Cartilage was harvested, then transferred for cell isolation and culture. Cells are suspended in agarose and transferred to cylindrical molds and surgically implanted 4 weeks later.
2
Mosaicoplasty
Mosaicoplasty
Osteochondral patch are sampled and then implanted during the same surgical procedure
Interventions
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Autologous chondrocytes transplantation
Cartilage was harvested, then transferred for cell isolation and culture. Cells are suspended in agarose and transferred to cylindrical molds and surgically implanted 4 weeks later.
Mosaicoplasty
Osteochondral patch are sampled and then implanted during the same surgical procedure
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* aged 18 to 50
* grade 3 or 4 lesion (ICRS) sized 2,5 cm2 to 7,5 cm2.
* IKDC score below 55
Exclusion Criteria
* allergy
* arthrosis
* varus or valgus angle greater than 10°
* ACL laxity
* Severe chronic disease
* BMI \> 30 Kg/m2
* HIV, B or C Hepatitis
18 Years
50 Years
ALL
No
Sponsors
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Institut National de la Santé Et de la Recherche Médicale, France
OTHER_GOV
University Hospital, Brest
OTHER
Responsible Party
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Principal Investigators
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F DUBRANA, PhD MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Brest
Locations
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CHU de Lyon
Lyon, Lyon, France
Orthopaedic surgery Departement Brest University Hospital
Brest, , France
CHU de Caen
Caen, , France
Centre médico chirurgical de Dracy-Le-Fort
Dracy-le-Fort, , France
CHU de Grenoble
Grenoble, , France
Ch Versailles
Le Chesnay, , France
Clinique Chenieux
Limoges, , France
CH Nord Mayenne
Mayenne, , France
CHU de Nancy
Nancy, , France
HIA Bégin
Saint-Mandé, , France
CHU de Strasbourg
Strasbourg, , France
Clinique du cours Dillon
Toulouse, , France
Countries
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References
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Clave A, Potel JF, Servien E, Neyret P, Dubrana F, Stindel E. Third-generation autologous chondrocyte implantation versus mosaicplasty for knee cartilage injury: 2-year randomized trial. J Orthop Res. 2016 Apr;34(4):658-65. doi: 10.1002/jor.23152. Epub 2016 Jan 18.
Other Identifiers
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RB 06.031
Identifier Type: -
Identifier Source: secondary_id
BB-01-C-01-OT
Identifier Type: -
Identifier Source: org_study_id
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