Regenerative Medicine of Articular Cartilage: Characterization and Comparison of Chondrogenic Potential and Immunomodulatory Adult Mesenchymal Stem Cells

NCT ID: NCT01879046

Last Updated: 2017-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2016-12-31

Brief Summary

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Articular cartilage can be the seat of many diseases including osteoarthritis and traumatic defaults. The cartilage has no intrinsic ability to repair resulting at long term in function loss in the joints. Currently available treatments are not satisfactory in the long term, the use of mesenchymal stem cells appears to be promising due to their ability to multipotency and immunomodulation properties. This project aims to determine the most appropriate source for regenerative medicine of cartilage stem cells from tissue taken during arthroplasty in patients with osteoarthritis. These cells will be tested for different chondrogenic markers. The success of this project will consider the implementation of a strategy for regenerative medicine in bone and joint diseases.

Detailed Description

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Conditions

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Knee Osteoarthritis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Surgical intervention

Blood, bone marrow and Hoffa's fat pad samplings during surgical intervention

Group Type EXPERIMENTAL

arthroplasty

Intervention Type PROCEDURE

Blood, bone marrow, synovial fluid and Hoffa's fat pad samplings

Interventions

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arthroplasty

Blood, bone marrow, synovial fluid and Hoffa's fat pad samplings

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients aged over 18 years
* Patients with knee osteoarthritis
* Patients requiring total knee arthroplasty
* Patients who signed the consent form

Exclusion Criteria

* Patients aged less than 18 years
* Major Patients under guardianship
* Pregnant woman
* Infectious pathology or progressive tumor
* Refusal to participate in the study
* State of immunosuppression
* Congenital or acquired malformation resulting in a deformation of the knee
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nantes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dr Ronan Guillou

Role: PRINCIPAL_INVESTIGATOR

Nantes University Hospital

Locations

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Nantes University Hospital

Nantes, , France

Site Status

Countries

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France

Other Identifiers

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RC12_0394

Identifier Type: -

Identifier Source: org_study_id

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