Functional Organization of Somatosensory Responses in the Secondary Somatosensitive Area and Insula

NCT ID: NCT00542906

Last Updated: 2009-06-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-10-31

Study Completion Date

2008-04-30

Brief Summary

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The implication of the second somatosensory area (SII) and the insular cortex in the processing of somatosensory inputs is now well established. However the functional anatomy of these areas hidden in the depth of the sylvian scissure remain mostly unknown.

The aim of this fMRI study is to determine the functional cartography of SII and insula. The localization of responses to different somatosensory stimuli (slight touch, warm, cold, heat pain and arthrokinesia) applied on the left hand of 25 healthy volunteers, will be compared.

Detailed Description

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Aims : Demonstrate that localization of the several types of somatosensory stimuli is different into SII and into insula. If possible, we'll determine a functional cartography of these areas.

Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

healthy volunteers

Group Type OTHER

localization

Intervention Type OTHER

localization of the several types of somatosensory stimuli

Interventions

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localization

localization of the several types of somatosensory stimuli

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 25 healthy volunteers will be included ranging in age from 18 to 50 years
* contraception needed for women
* right handed
* All the subjects have to give their written informed consent.

Exclusion Criteria

* pregnancy
* neurological or psychiatric disease
* drugs taken \<12h before fMRI
* contra-indications to fMRI : pacemaker, clip, metallic device
* Refusing to be informed of the presence of a cerebral abnormality, detected during MRI.
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role lead

Responsible Party

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Centre Hospitalier Universitaire de Saint Etienne

Principal Investigators

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Laure Mazzola, MD

Role: PRINCIPAL_INVESTIGATOR

CHU de Saint-Etienne

Locations

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Service de Neurologie - CHU de Saint-Etienne

Saint-Etienne, , France

Site Status

Countries

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France

References

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Mazzola L, Isnard J, Mauguiere F. Somatosensory and pain responses to stimulation of the second somatosensory area (SII) in humans. A comparison with SI and insular responses. Cereb Cortex. 2006 Jul;16(7):960-8. doi: 10.1093/cercor/bhj038. Epub 2005 Sep 21.

Reference Type BACKGROUND
PMID: 16177270 (View on PubMed)

Peyron R, Schneider F, Faillenot I, Convers P, Barral FG, Garcia-Larrea L, Laurent B. An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic pain. Neurology. 2004 Nov 23;63(10):1838-46. doi: 10.1212/01.wnl.0000144177.61125.85.

Reference Type BACKGROUND
PMID: 15557499 (View on PubMed)

Other Identifiers

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2007-A00328-45

Identifier Type: -

Identifier Source: secondary_id

DGS 2007-0273

Identifier Type: -

Identifier Source: secondary_id

0701023

Identifier Type: -

Identifier Source: org_study_id

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