Anterior Insula Regulation and Pain Empathy

NCT ID: NCT02463981

Last Updated: 2022-02-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 37 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-06-30
• Study Completion Date: 2015-07-31

Brief Summary

The aim is to test whether rtfMRI-based neurofeedback training on anterior insula impacts pain empathy.

Detailed Description

In the present study, investigators plan to use the real-time fMRI neurofeedback to train healthy subjects to learn volitional control over their own anterior insula (AI) activity. Then the effect of AI regulation will assessed by examining subjects' empathic responses and functional connectivity changes. Subjects were separated into two groups randomly. While the experimental group received specific neurofeedback from their own AI, the control group received sham NF from an unspecific region.

Conditions

Anterior Insula Activity During Regulation; Empathic Responses After Anterior Insula Regulation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

neurofeedback training

Neurofeedback training group receives neurofeedback from their own anterior insula.

Group Type: EXPERIMENTAL

real-time fMRI neurofeedback training running on Turbo Brain voyager (TBV) 3.2 (Brain Innovation, Maastricht, The Netherlands)

Intervention Type: DEVICE

sham control

Sham control group receives sham neurofeedback from a large control brain region.

Group Type: SHAM_COMPARATOR

real-time fMRI neurofeedback training running on Turbo Brain voyager (TBV) 3.2 (Brain Innovation, Maastricht, The Netherlands)

Intervention Type: DEVICE

Interventions

real-time fMRI neurofeedback training running on Turbo Brain voyager (TBV) 3.2 (Brain Innovation, Maastricht, The Netherlands)

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria

• history of head injury;
• claustrophobia;
• pregnancy;
• medical or psychiatric illness.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Electronic Science and Technology of China

OTHER

Sponsor Role: lead

Responsible Party

Shuxia Yao

PhD student

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Keith Kendrick, Dr.

Role: PRINCIPAL_INVESTIGATOR

University of Electronic Science and Technology of China

Other Identifiers

UESTC-SCAN-02

Identifier Type: -

Identifier Source: org_study_id