How to Improve Diagnosis in Infective Endocarditis

NCT ID: NCT00524212

Last Updated: 2010-01-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

761 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-03-31

Study Completion Date

2009-05-31

Brief Summary

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The purpose is to exam prospective if simple clinical information in combination with a normal s-procalcitonin are sufficient for exclusion of infective endocarditis (IE).

Detailed Description

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Despite progress in surgical and medical treatment, infective endocarditis is still associated with high morbidity and mortality.

The variable clinical presentation of IE makes the diagnosis a clinical challenge.

Procalcitonin is a precursor from the hormone calcitonin and also a marker of systemic bacterial infections.

The purpose of this study is:

* to investigate the diagnostic value of serum procalcitonin (PCT), C-reactive protein (CRP) and sedimentation rate (SR) when IE is suspected.
* to investigate if a retrospectively generated clinical model suitable for exclusion of IE can be confirmed prospectively.

Conditions

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Endocarditis, Bacterial

Study Design

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Study Time Perspective

PROSPECTIVE

Study Groups

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IE confirmed IE rejected

Prospective, controlled, blinded study of clinical/TEE criteria of IE compare to clinical/blood test criteria of IE.

No interventions assigned to this group

IE confirmed IE rejected

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients \> or = 18 year with suspected or verified Infective Endocarditis
* By word of mouth or in writing consent

Exclusion Criteria

* Incapacity
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Dept. of Cardiology, Aarhus University Hospital, Skejby - Denmark

Principal Investigators

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Jane B Knudsen, Dr.

Role: PRINCIPAL_INVESTIGATOR

Aarhus University Hospital, Skejby, Department of Cardiology, 8200 Aarhus N, Denmark

Locations

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Department of Cardiology, Aarhus University Hospital

Aarhus, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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20060181

Identifier Type: -

Identifier Source: secondary_id

SUN-2007-653

Identifier Type: -

Identifier Source: secondary_id

06-10-B640-A1205-22345

Identifier Type: -

Identifier Source: org_study_id

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