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The Effects of Trout Fed With a Vegetable Based Feed on Cardiovascular Risk Markers and Plasma Proteome

NCT ID: NCT00445614

Last Updated: 2008-08-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

72 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-03-31

Study Completion Date

2007-12-31

Brief Summary

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Fish from the aquaculture sector constitutes an increasing part of the fish consumption in Denmark. The most important farmed fish in Denmark is the rainbow trout. Due to limited access of wild fish for the feed production, alternative feeding regimes of vegetable origin such as vegetable proteins and rapeseed oil are used instead of marine feed. This change in feeding regime may affect flesh quality and health and nutritional properties as the content of long-chain n-3 polyunsaturated fatty acids (n-3 LCPUFA) will presumably decrease in the meat. The objective of the study is to investigate the effect of vegetable based feed versus marine feed of farmed trout and its effect in healthy men on cardiovascular risk markers associated with the development of cardiovascular disease (CVD).

Detailed Description

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In a two month parallel study including 60 healthy men aged 40-70 years, the cardiovascular effect of one daily meal of trout fed with a vegetable based feed are compared with that of trout fed with marine feed (estimated intake of n-3 LCPUFA 2.6 g/day) and a standard Danish diet with poultry. Men are randomised to one of the three groups. Red blood cell fatty acid composition, classical cardiovascular disease (CVD)-risk markers (blood pressure and plasma lipid profile), newer CVD-markers (arterial compliance and plasma markers of endothelial function and inflammation) and plasma proteome analysis are measured at the beginning and end of the intervention period.

Conditions

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Cardiovascular Disease

Keywords

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nutrition cardiovascular risk inflammation vascular function

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Study Groups

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Marine trout

150 g/day of trout fed on marine based feed

Group Type EXPERIMENTAL

Effects of trout on CVD risk markers and plasma proteome

Intervention Type BEHAVIORAL

Vegetable trout

150 g/d of trout fed on vegetable based feed

Group Type EXPERIMENTAL

Effects of trout on CVD risk markers and plasma proteome

Intervention Type BEHAVIORAL

Poultry

150 g/d of poultry (for comparison)

Group Type OTHER

Effects of trout on CVD risk markers and plasma proteome

Intervention Type BEHAVIORAL

Interventions

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Effects of trout on CVD risk markers and plasma proteome

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Age 40-70
* Body mass index 18,5 - 30

Exclusion Criteria

* Exercise \>10 h/week
* Chronical diseases (eg. cardiovascular and diabetes)
* Regular medication
* Fish oil supplementation
* Blood donation 2 month prior or during participation
* Above maximum recommended alcohol intake
* Blood pressure \>160/100 mm Hg
Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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The Ministry of Science, Technology and Innovation, Denmark

OTHER_GOV

Sponsor Role collaborator

Danish Institute of Fisheries Research

OTHER

Sponsor Role collaborator

University of Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Dept. of Human Nutrition, University of Copenhagen

Principal Investigators

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Lotte Lauritzen, ph.d.

Role: PRINCIPAL_INVESTIGATOR

University of Copenhagen

Locations

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Department of Human Nutrition, Denmark

Frederiksberg, Frederiksberg, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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M187

Identifier Type: -

Identifier Source: org_study_id