Vasoactive Hormones and Oxygen Saturation During Apneic Events in Patients With Obstructive Sleep Apnea

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-10-31

Brief Summary

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The mechanisms involved in development and maintenance of hypertension in obstructive sleep apnea are not clarified.

We hypothesize that patients with obstructive sleep apnea have an abnormal level of some vasoactive hormones during apneic events during sleep.

Detailed Description

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Conditions

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Obstructive Sleep Apnea

Keywords

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Noradrenalin Endothelin-1 Angiotensin II Arginine vasopressin Aldosterone Renin Atrial natriuretic peptide Brain natriuretic peptide Blood pressure Apnea

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Severe obstructive sleep apnea (apnea-hypopnea index \> 30)

* Apnea-hypopnea index \< 10

Exclusion Criteria

* Drug or alcohol abuse
* Pregnancy
* History or clinical signs of disease in the heart, lungs, brain, liver, kidneys or endocrine organs
* Diabetes

Healthy Controls

* Drug or alcohol abuse
* Pregnancy
* History or clinical signs of disease in the heart, lungs, brain, liver, kidneys or endocrine organs
* Diabetes

Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Department of Medical Research

Principal Investigators

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Erling B Pedersen, Professor

Role: STUDY_CHAIR

Regional Hospital Holstebro

Locations

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Department of Medical Research, Holstebro Hospital

Holstebro, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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MED.RES.HOS.2006.01.PHH

Identifier Type: -

Identifier Source: org_study_id