Central and Peripheral Blood Pressure in Treatment of Obstructive Sleep Apnea.
NCT ID: NCT02078778
Last Updated: 2015-02-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2014-02-28
2017-03-31
Brief Summary
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Hypothesis:
1. Central 24-h blood pressure (BP) monitoring hedges day fluctuations in blood pressure more accurately than peripheral 24-h BP monitoring, because the measurement is painless and does not interfere with the patient / subject's activities during the daytime or nighttime sleep.
2. Blood pressure is elevated in patients with OSA and falls during treatment with CPAP.
3\. The renal treatment of salt and water is abnormal in OSA, improved during treatment with CPAP.
4\. Quality of life improves during treatment with CPAP
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Detailed Description
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Before and after 3 months of CPAP treatment is made central and peripheral 24-h ambulatory blood pressure monitoring, 24-h urine collection and blood samples.
Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Treatment
Patients with hypertension and moderate to severe OSA is treated with CPAP for 3 months.
CPAP
3 months of CPAP treatment
Interventions
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CPAP
3 months of CPAP treatment
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Obstructive sleep apnea, apnea hypopnea index (AHI) \> 15 (moderate to severe)
* Both men and women
* 55-70 years
* Signed consent form
Exclusion Criteria
* Malignant disease
* Abuse of drugs or alcohol
* Pregnant and breastfeeding
* Incompensated heart failure
* Atrial fibrillation
* Liver disease (Alanine aminotransferase (ALT) \> 200)
* Severe chronic obstructive pulmonary disease (Forced expiratory volume in 1 second \<50% predicted)
* Blood pressure difference between the right and left arm\> 10/10 mmHg
55 Years
70 Years
ALL
No
Sponsors
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Erling Bjerregaard Pedersen
OTHER
Responsible Party
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Erling Bjerregaard Pedersen
professor
Locations
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Department of Medical Research and Medicine, Holstebro Regional Hospital
Holstebro, Holstebro, Denmark
Countries
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Facility Contacts
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Other Identifiers
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M-2013-304-13
Identifier Type: OTHER
Identifier Source: secondary_id
BGH-4-2013
Identifier Type: -
Identifier Source: org_study_id
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