Changes in Different Fat Compartments and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures.
NCT ID: NCT00431587
Last Updated: 2008-04-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
1000 participants
OBSERVATIONAL
2007-06-30
Brief Summary
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The amount of fat lost from each site may be independently regulated. Very scant information is found in the literature regarding the relative changes in different fat body compartments, and their effect on the improvement of the metabolic profile.
In this study we define the absolute and relative changes in the different adipose tissue compartment after weight loss surgery
Detailed Description
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The amount of fat lost from each site may be independently regulated. Very scant information is found in the literature regarding the relative changes in different fat body compartments.
Rapid and preferential reduction of visceral fat mass could occur in morbid obese with visceral obesity. It has been previously shown, and it was also partially confirmed in this study, that a reduction in visceral fat was associated with metabolic improvements that included improved glucose tolerance and reduced plasma insulin and lipid levels.
This again suggests a threshold of proportional visceral fat loss, above which there is an improvement in insulin sensitivity and other component of metabolic syndrom.
We will quantify the different fat compartments changes after bariatric surgery by means of CT scan.
Conditions
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Keywords
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Study Design
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PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Metabolic syndrome
Exclusion Criteria
* Previous major abdominal surgey
18 Years
65 Years
ALL
No
Sponsors
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Hadassah Medical Organization
OTHER
Principal Investigators
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Andrei Keidar, MD
Role: PRINCIPAL_INVESTIGATOR
Hadassah Medical Organization
Locations
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Hadassah Medical Organization,
Jerusalem, , Israel
Countries
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Central Contacts
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Facility Contacts
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Arik Tzukert, DMD
Role: primary
Hadas Lemberg, PhD
Role: backup
References
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Weiss R, Appelbaum L, Schweiger C, Matot I, Constantini N, Idan A, Shussman N, Sosna J, Keidar A. Short-term dynamics and metabolic impact of abdominal fat depots after bariatric surgery. Diabetes Care. 2009 Oct;32(10):1910-5. doi: 10.2337/dc09-0943. Epub 2009 Jul 8.
Other Identifiers
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metabo-HMO-CTIL
Identifier Type: -
Identifier Source: org_study_id