Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
106 participants
OBSERVATIONAL
2010-05-31
Brief Summary
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Objective: The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood.
Design: In the longitudinal observational study, the investigator applied a 1H-NMR-based global, untargeted metabolomics strategy on human serum samples that were collected before and repeatedly up to one year after distinct bariatric procedures (sleeve gastrectomy, proximal and distal Roux-en Y gastric bypass; RYGB). For comparison, the investigator also analyzed serum samples from normal-weight and less obesity obese subjects that were matched for 1-year postoperative BMI values of the surgical groups.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Sleeve group
Patients undergoing gastric sleeve resection.
bariatric surgery (sleeve resection, proximal RYGB, distal RYGB)
Proximal RYGB group
Patients undergoing proximal gastric bypass surgery.
bariatric surgery (sleeve resection, proximal RYGB, distal RYGB)
Distal RYGB group
Patients undergoing distal gastric bypass surgery.
bariatric surgery (sleeve resection, proximal RYGB, distal RYGB)
BMI-matched control group
No interventions assigned to this group
Normal-weight control group
No interventions assigned to this group
Interventions
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bariatric surgery (sleeve resection, proximal RYGB, distal RYGB)
Eligibility Criteria
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Inclusion Criteria
* at least 2 years of unsuccessful conservative weight loss attempts
Exclusion Criteria
* BMI \< 35 kg/m2
* informed consent was not signed by the patient
18 Years
70 Years
ALL
Yes
Sponsors
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University of Florence
OTHER
FiorGen Foundation, Italy
UNKNOWN
eSwiss Medical & Surgical Center
OTHER
Responsible Party
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References
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Gralka E, Luchinat C, Tenori L, Ernst B, Thurnheer M, Schultes B. Metabolomic fingerprint of severe obesity is dynamically affected by bariatric surgery in a procedure-dependent manner. Am J Clin Nutr. 2015 Dec;102(6):1313-22. doi: 10.3945/ajcn.115.110536. Epub 2015 Nov 18.
Other Identifiers
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Metab-001
Identifier Type: -
Identifier Source: org_study_id
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