Glucose Homeostasis Pre and Post Bariatric Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-12-31

Study Completion Date

2018-06-30

Brief Summary

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The investigators wish to study the effects of three forms of bariatric surgery: Roux-en-Y gastric bypass, Sleeve Gastrectomy, and Gastric Banding. The surgery is not part of the clinical trial. If your insurance does not cover the procedure, then you are responsible for payment of the surgical process. We are doing pre and post surgery testing to provide a better understanding of the effect of bariatric surgery-induced weight loss on metabolic function.

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Detailed Description

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Bariatric surgery is the most effective weight loss therapy for obesity. Moreover, the early improvement in insulin sensitivity and the resolution of type 2 diabetes after bariatric surgery has led to the hypothesis that bariatric surgery has specific beneficial effects on glucose homeostasis beyond weight loss alone. However, this hypothesis has never been adequately evaluated in human subjects. Therefore, the primary goal of this proposal is to provide a better understanding of the effect of bariatric surgery-induced weight loss on insulin action and pancreatic beta cell function.

Conditions

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Morbid Obesity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Gastric Bypass

morbidly obese subjects undergoing gastric bypass surgery

gastric bypass

Intervention Type PROCEDURE

Roux-en-Y gastric bypass

gastric banding

morbidly obese subjects undergoing laparoscopic gastric banding surgery

gastric banding

Intervention Type PROCEDURE

laparoscopic adjustable gastric banding

sleeve gastrectomy

morbidly obese subjects undergoing sleeve gastrectomy

sleeve gastrectomy

Intervention Type PROCEDURE

vertical sleeve gastrectomy

Interventions

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gastric bypass

Roux-en-Y gastric bypass

Intervention Type PROCEDURE

gastric banding

laparoscopic adjustable gastric banding

Intervention Type PROCEDURE

sleeve gastrectomy

vertical sleeve gastrectomy

Intervention Type PROCEDURE

Other Intervention Names

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Roux-en-Y gastric bypass lap band gastric sleeve

Eligibility Criteria

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Inclusion Criteria

* BMI ≥ 35 kg/m²
* on stable dose of medications for at least 4 weeks before the pre-surgery metabolic studies

Exclusion Criteria

* smokes \> 7 cigarettes per day
* previous malabsorptive or restrictive intestinal surgery
* pregnant or breastfeeding
* recent history of neoplasia (\< 5 years ago)
* have malabsorptive syndromes and inflammatory intestinal disease
* diabetes mellitus
* show signs of oral disease or xerostomia (i.e., dry mouth)
* history of chronic rhinitis
* on medication that might affect metabolism
* severe organ dysfunction

Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No