Interruption of Dorsal Visual Stream Using TMS

NCT ID: NCT00418652

Last Updated: 2011-08-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-01-31

Brief Summary

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Trans Cranial Magnetic Stimulation (TMS) over dorsal visual system will disturb the ability to identify objects with decreased level of fragmentation

Detailed Description

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The participants performed two tasks under three different TMS conditions: no TMS, 10Hz TMS for over the dorsal stream (PO3 EEG site) or over the vertex.

First they performed a perceptual closure task which asked them to identify an object in a series of six progressively less degraded pictures.

Then, they also performed a control task previously shown not to be mediated by the LOC and not to be impaired in schizophrenia: The perception of illusory contours.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Participants

Study Groups

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No TMS stimulation

The patients performed 2 tasks: a study and a control assignments with no TMS stimulation.

Group Type NO_INTERVENTION

No TMS intervention

Intervention Type DEVICE

In the "no TMS" condition, no simulation was given and no coil placed near participants' heads.

TMS over the dorsal stream

The patients performed 2 tasks: a study and a control assignments under TMS stimulation over the dorsal stream area (PO3 EEG site).

Group Type EXPERIMENTAL

TMS over the PO3 EEG site

Intervention Type DEVICE

10Hz TMS over the dorsal stream (PO3 EEG site)

TMS over the vertex

The patients performed 2 tasks: a study and a control assignments under TMS stimulation over the vertex area.

Group Type SHAM_COMPARATOR

TMS over the vertex

Intervention Type DEVICE

10Hz TMS for over vertex.

Interventions

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No TMS intervention

In the "no TMS" condition, no simulation was given and no coil placed near participants' heads.

Intervention Type DEVICE

TMS over the PO3 EEG site

10Hz TMS over the dorsal stream (PO3 EEG site)

Intervention Type DEVICE

TMS over the vertex

10Hz TMS for over vertex.

Intervention Type DEVICE

Other Intervention Names

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MAGSTIM biphasic stimulator MAGSTIM biphasic stimulator

Eligibility Criteria

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Inclusion Criteria

* Normal controls

Exclusion Criteria

* neurological, ophthalmological or psychiatric problems
* family history of schizophrenia
* left handed
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sheba Medical Center

OTHER_GOV

Sponsor Role lead

Responsible Party

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Sheba Medical Center

Principal Investigators

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Revital Amiaz, MD

Role: PRINCIPAL_INVESTIGATOR

Sheba Medical Center

Locations

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Psychiatry Clinic - Sheba Medical Center

Tel Litwinsky, , Israel

Site Status

Countries

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Israel

Other Identifiers

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SHEBA-06-4252-RA-CTIL

Identifier Type: -

Identifier Source: org_study_id

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