Study on the Effect of Transcranial Magnetic Stimulation on the Perception of Emotional Images
NCT ID: NCT07191275
Last Updated: 2025-11-21
Study Results
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Basic Information
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RECRUITING
NA
33 participants
INTERVENTIONAL
2025-11-01
2026-10-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Participants starting with experimental condition
Bilateral continuous theta burst stimulation (cTBS) 30 Hz to the temporo-occipital cortex
Experimental continuous 30 Hz thetaburst transcranial magnetic stimulation
Bilateral continuous theta burst stimulation (cTBS) 30 Hz to the temporo-occipital cortex
* Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
* Intensity: 100% of resting motor threshold (rMT)
* Location: consecutively on left and right temporo-occipital cortex (MNI: -47, -77, 4; 50, -69, -4)
* Duration: 33.3 seconds for each side
* Timing: Immediately before showing IAPS pictures (off-line)
Control continuous 30 Hz thetaburst transcranial magnetic stimulation
Active control condition using bilateral continuous theta burst stimulation (cTBS) 30 Hz to the superior parietal cortex
* Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
* Intensity: 100% of resting motor threshold (rMT)
* Location: consecutively on left and right superior parietal cortex (MNI: -17, -70, 60; 17, -70, 60)
* Duration: 33.3 seconds
* Timing: Immediately before showing IAPS pictures (off-line)
Participants starting with control condition
Active control condition using bilateral continuous theta burst stimulation (cTBS) 30 Hz to the superior parietal cortex
Experimental continuous 30 Hz thetaburst transcranial magnetic stimulation
Bilateral continuous theta burst stimulation (cTBS) 30 Hz to the temporo-occipital cortex
* Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
* Intensity: 100% of resting motor threshold (rMT)
* Location: consecutively on left and right temporo-occipital cortex (MNI: -47, -77, 4; 50, -69, -4)
* Duration: 33.3 seconds for each side
* Timing: Immediately before showing IAPS pictures (off-line)
Control continuous 30 Hz thetaburst transcranial magnetic stimulation
Active control condition using bilateral continuous theta burst stimulation (cTBS) 30 Hz to the superior parietal cortex
* Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
* Intensity: 100% of resting motor threshold (rMT)
* Location: consecutively on left and right superior parietal cortex (MNI: -17, -70, 60; 17, -70, 60)
* Duration: 33.3 seconds
* Timing: Immediately before showing IAPS pictures (off-line)
Interventions
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Experimental continuous 30 Hz thetaburst transcranial magnetic stimulation
Bilateral continuous theta burst stimulation (cTBS) 30 Hz to the temporo-occipital cortex
* Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
* Intensity: 100% of resting motor threshold (rMT)
* Location: consecutively on left and right temporo-occipital cortex (MNI: -47, -77, 4; 50, -69, -4)
* Duration: 33.3 seconds for each side
* Timing: Immediately before showing IAPS pictures (off-line)
Control continuous 30 Hz thetaburst transcranial magnetic stimulation
Active control condition using bilateral continuous theta burst stimulation (cTBS) 30 Hz to the superior parietal cortex
* Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
* Intensity: 100% of resting motor threshold (rMT)
* Location: consecutively on left and right superior parietal cortex (MNI: -17, -70, 60; 17, -70, 60)
* Duration: 33.3 seconds
* Timing: Immediately before showing IAPS pictures (off-line)
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Normotensive (BP 90/60mmHg - 140/90mmHg)
* BMI: 18 - 30 kg/m2
* Fluent in speaking German
Exclusion Criteria
* Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS)
* Cardiac pacemaker or intracardiac lines
* Medication infusion device
* Non removable metal piercings in the head area, pivot teeth (retainers are no exclusion criterion)
* Tattoos (head area) less than 3 months old or older than 20 years
* Condition after neurosurgery
* Hearing problems or tinnitus
* Not able to sit still due to tremor, tics, itching
* History of repeated syncope
* Head trauma diagnosed as concussion or associated with loss of consciousness
* diagnosis of epilepsy, or a convulsion or a seizure in the past of the participant or his/her close family (parents and siblings)
* TMS in the past showing problems
* Spinal or ventricular derivations
* Positive pregnancy test
* Alcohol intake 12 hours before TMS visits
* Regular intake of any medication (excluding oral contraceptives)
* CNS-active medication or illegal drugs 48h before TMS visits
* Individual's rMT above the limits of rTMS device
* Suicidal tendency as measured by Montgomery-Åsberg Depression Rating Scale (MADRS), item 10 \> 0
18 Years
30 Years
ALL
Yes
Sponsors
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Prof. Dominique de Quervain, MD
OTHER
Responsible Party
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Prof. Dominique de Quervain, MD
Director Division of Cognitive Neuroscience
Principal Investigators
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Dominique de Quervain, MD
Role: PRINCIPAL_INVESTIGATOR
University of Basel, Division of Cognitive Neuroscience
Locations
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University of Basel, Division of Cognitive Neuroscience
Basel, Canton of Basel-City, Switzerland
Countries
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Central Contacts
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Facility Contacts
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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2025-01622
Identifier Type: -
Identifier Source: org_study_id
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