Influence of Temporo-occipital Transcranial Magnetic Brain Stimulation on Aversive Episodic Memory Performance
NCT ID: NCT05847933
Last Updated: 2025-07-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
105 participants
INTERVENTIONAL
2023-06-06
2025-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SEQUENTIAL
BASIC_SCIENCE
NONE
Study Groups
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cTBS 50 Hz experiment
Active brain stimulation on the temporo-occipital cortex using the cTBS 50 Hz protocol.
rTMS (cTBS 50Hz experiment)
rTMS using cTBS protocol with the following characteristics:
* Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band)
* Intensity: 80% of resting motor threshold (rMT)
* Location: consecutively on the left and right temporo-occipital cortex (MNI coordinates: left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0)
* Duration: 40 seconds for each hemisphere, 80 seconds in total.
* Timing: Immediately before viewing pictures in pictorial memory task (off-line)
cTBS sham
Sham brain stimulation on the temporo-occipital cortex using the cTBS 50Hz protocol pattern
rTMS (cTBS sham)
rTMS using cTBS protocol with the following characteristics:
* Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band)
* Intensity: 0%
* Location: consecutively on the left and right temporo-occipital cortex (MNI coordinates: left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0)
* Duration: 40 seconds for each hemisphere, 80 seconds in total.
* Timing: Immediately before viewing pictures in pictorial memory task (off-line)
cTBS 50Hz active control
Active brain stimulation on the right superior frontal cortex using the cTBS 50 Hz protocol
rTMS (cTBS 50 Hz active control)
rTMS using cTBS protocol with the following characteristics:
* Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band)
* Intensity: 80% of resting motor threshold (rMT)
* Location: Right superior frontal cortex
* Duration: 40 seconds for each hemisphere, 80 seconds in total.
* Timing: Immediately before viewing pictures in pictorial memory task (off-line)
High frequency
Active brain stimulation on the temporo-occipital cortex using the 20Hz protocol
rTMS (high frequency)
rTMS using high frequency protocol with the following characteristics:
* Frequency: 20 Hz
* Intensity: 120% of rMT for rMT \< 54% \& 65% of MSO for rMT ≥ 54%
* Location: temporo-occipital cortex of the dominant brain hemisphere
* Duration: 20 minutes, continuously
* Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
Low frequency
Active brain stimulation on the temporo-occipital cortex using the 1Hz protocol
rTMS (low frequency)
rTMS using Low frequency protocol with the following characteristics:
* Frequency: 1 Hz
* Intensity: 110% of rMT
* Location: temporo-occipital cortex of dominant brain hemisphere (MNI left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0)
* Duration: 30 minutes, continuously
* Timing: Starting 10 minutes before and continuing during the picture viewing and valence rating of the pictures of the memory task (on-line).
cTBS 30Hz
Active brain stimulation on the temporo-occipital cortex using the cTBS 30 Hz protocol.
rTMS (cTBS 30 Hz)
* Bilateral continuous theta burst stimulation (cTBS) 30 Hz:
* Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
* Intensity: 100% of resting motor threshold (rMT)
* Location: consecutively on left and right temporo-occipital cortex
* Duration: 33.3 seconds for each side
* Timing: Immediately before pictorial memory task (off-line)
cTBS 30 Hz Active control
Active brain stimulation on the right superior frontal cortex using the cTBS 30 Hz protocol
rTMS ( cTBS 30 Hz active control)
* Bilateral continuous theta burst stimulation (cTBS) 30 Hz:
* Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
* Intensity: 100% of resting motor threshold (rMT)
* Location: consecutively on right superior frontal cortex
* Duration: 33.3 seconds for each side
* Timing: Immediately before pictorial memory task (off-line)
High frequency Active control
Active brain stimulation on the right superior frontal cortex using the 20 Hz online protocol
rTMS (high frequency active control)
* Frequency: 20 Hz
* Intensity: 120% of rMT for rMT \< 54% \& 65% of MSO for rMT ≥ 54%
* Location: right superior frontal cortex of the dominant brain hemisphere
* Duration: 20 minutes, continuously
* Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
Low frequency Active control
Active brain stimulation on the right superior frontal cortex using the 1 Hz offline protocol
rTMS (low frequency active control )
* Frequency: 1 Hz
* Intensity: 110% of rMT
* Location: Right superior frontal cortex of the dominant brain hemisphere
* Duration: 6 minutes
* Timing: Starting 1 minutes before and continuing during the memory task (Online)
High frequency sham
Brain stimulation on the dominant temporo-occipital cortex using 10% maximum system output (MSO) and 20 Hz online protocol.
rTMS (high frequency sham)
* Frequency: 20 Hz
* Intensity: 10% of MSO
* Location: temporo-occipital cortex of the dominant brain hemisphere
* Duration: 20 minutes, continuously
* Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
Interventions
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rTMS (cTBS 50Hz experiment)
rTMS using cTBS protocol with the following characteristics:
* Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band)
* Intensity: 80% of resting motor threshold (rMT)
* Location: consecutively on the left and right temporo-occipital cortex (MNI coordinates: left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0)
* Duration: 40 seconds for each hemisphere, 80 seconds in total.
* Timing: Immediately before viewing pictures in pictorial memory task (off-line)
rTMS (cTBS sham)
rTMS using cTBS protocol with the following characteristics:
* Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band)
* Intensity: 0%
* Location: consecutively on the left and right temporo-occipital cortex (MNI coordinates: left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0)
* Duration: 40 seconds for each hemisphere, 80 seconds in total.
* Timing: Immediately before viewing pictures in pictorial memory task (off-line)
rTMS (cTBS 50 Hz active control)
rTMS using cTBS protocol with the following characteristics:
* Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band)
* Intensity: 80% of resting motor threshold (rMT)
* Location: Right superior frontal cortex
* Duration: 40 seconds for each hemisphere, 80 seconds in total.
* Timing: Immediately before viewing pictures in pictorial memory task (off-line)
rTMS (high frequency)
rTMS using high frequency protocol with the following characteristics:
* Frequency: 20 Hz
* Intensity: 120% of rMT for rMT \< 54% \& 65% of MSO for rMT ≥ 54%
* Location: temporo-occipital cortex of the dominant brain hemisphere
* Duration: 20 minutes, continuously
* Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
rTMS (low frequency)
rTMS using Low frequency protocol with the following characteristics:
* Frequency: 1 Hz
* Intensity: 110% of rMT
* Location: temporo-occipital cortex of dominant brain hemisphere (MNI left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0)
* Duration: 30 minutes, continuously
* Timing: Starting 10 minutes before and continuing during the picture viewing and valence rating of the pictures of the memory task (on-line).
rTMS (high frequency sham)
* Frequency: 20 Hz
* Intensity: 10% of MSO
* Location: temporo-occipital cortex of the dominant brain hemisphere
* Duration: 20 minutes, continuously
* Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
rTMS (high frequency active control)
* Frequency: 20 Hz
* Intensity: 120% of rMT for rMT \< 54% \& 65% of MSO for rMT ≥ 54%
* Location: right superior frontal cortex of the dominant brain hemisphere
* Duration: 20 minutes, continuously
* Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
rTMS (low frequency active control )
* Frequency: 1 Hz
* Intensity: 110% of rMT
* Location: Right superior frontal cortex of the dominant brain hemisphere
* Duration: 6 minutes
* Timing: Starting 1 minutes before and continuing during the memory task (Online)
rTMS ( cTBS 30 Hz active control)
* Bilateral continuous theta burst stimulation (cTBS) 30 Hz:
* Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
* Intensity: 100% of resting motor threshold (rMT)
* Location: consecutively on right superior frontal cortex
* Duration: 33.3 seconds for each side
* Timing: Immediately before pictorial memory task (off-line)
rTMS (cTBS 30 Hz)
* Bilateral continuous theta burst stimulation (cTBS) 30 Hz:
* Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band)
* Intensity: 100% of resting motor threshold (rMT)
* Location: consecutively on left and right temporo-occipital cortex
* Duration: 33.3 seconds for each side
* Timing: Immediately before pictorial memory task (off-line)
Eligibility Criteria
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Inclusion Criteria
* Generally healthy
* Normotensive (BP 90/60mmHg - 140/90mmHg)
* BMI: 19 - 30 kg/m2
* Age: 18 - 30 years
* Fluent German-speaking
Exclusion Criteria
* Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS)
* Cardiac pacemaker or intracardiac lines
* Medication infusion device
* Nonremovable Piercings in the head area, pivot teeth (retainers are no exclusion criterion)
* Tattoos (head area) less than 3 months old or older than 20 years
* Condition after neurosurgery
* Hearing problems or tinnitus
* Not able to sit still due to tremor, tics, itching
* History of repeated syncope
* Head trauma diagnosed as concussion or associated with loss of consciousness
* diagnosis of epilepsy, or a convulsion or a seizure in the past of the participant or his/her close family
* TMS in the past showing problems
* Surgical procedures to spinal cord
* Spinal or ventricular derivations
* Alcohol or drug intake 48 hours before start of visits
* Regular intake of any medication or CNS-active medication 48h before visit
* rMT above the limits of rTMS device.
18 Years
30 Years
ALL
Yes
Sponsors
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Prof. Dominique de Quervain, MD
OTHER
Responsible Party
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Prof. Dominique de Quervain, MD
Director Division of Cognitive Neuroscience
Principal Investigators
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Dominique de Quervain, Prof. MD
Role: STUDY_CHAIR
University of Basel, Research Platform Molecular and Cognitive Neuroscience
Locations
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University of Basel, Division of Cognitive Neuroscience
Basel, Canton of Basel-City, Switzerland
Countries
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Other Identifiers
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2023-00392
Identifier Type: -
Identifier Source: org_study_id
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