Transcranial Magnetic Stimulation in Mild Cognitive Impairment and Alzheimer Disease

NCT ID: NCT04771845

Last Updated: 2021-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

73 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-05-01

Study Completion Date

2020-05-30

Brief Summary

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The investigators reviewed 12 years of clinical use in an outpatient neurology setting of transcranial magnetic stimulation (TMS) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) to evaluate safety and efficacy of TMS.

Detailed Description

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The investigators compiled demographic, clinical, and neurocognitive data on all patients who had received TMS for any reason in the clinic over a 12-year period. Of 236 patients receiving TMS, 59 patients with AD and 14 with MCI satisfied study criteria and were compared to controls from the National Alzheimer's Coordinating Center (NACC). Neurocognitive outcomes were compared between magnetic resonance imaging (MRI) and electroencephalogram (EEG)-grid guided TMS in patients. Tolerability data was reviewed for all patients.

Conditions

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Alzheimer Disease Mild Cognitive Impairment

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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EEG-grid-guided-TMS

Patients with Alzheimer disease and mild cognitive impairment receiving TMS using electroencephalogram grid guided navigation

Transcranial Magnetic Stimulation

Intervention Type DEVICE

Magnetic stimulation to alter neural activity

MRI-guided-TMS

Patients with Alzheimer disease and mild cognitive impairment receiving TMS using MRI guided navigation

Transcranial Magnetic Stimulation

Intervention Type DEVICE

Magnetic stimulation to alter neural activity

NACC controls

National Alzheimer's Coordinating Center matched controls

No interventions assigned to this group

Interventions

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Transcranial Magnetic Stimulation

Magnetic stimulation to alter neural activity

Intervention Type DEVICE

Other Intervention Names

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TMS

Eligibility Criteria

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Inclusion Criteria

* Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for possible or probable Alzheimer's disease.
* Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for mild cognitive impairment.
* Patients must have undergone at least two standardized neurocognitive batteries before and after beginning TMS.
* Patients must have received greater than or equal to five (5) TMS sessions in less than one year.

Exclusion Criteria

• Patients with dementias from other causes, such as Lewy Body disease.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The New York Memory Services

OTHER

Sponsor Role lead

Responsible Party

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Gayatri Devi, MD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gayatri Devi, MD

Role: PRINCIPAL_INVESTIGATOR

NY Memory

Other Identifiers

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20-0812

Identifier Type: -

Identifier Source: org_study_id

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