Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

23 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-31

Study Completion Date

2007-07-31

Brief Summary

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Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this condition have different patterns of cerebrovascular reactivity and whether it is possible to predict the development of septic encephalopathy from early measurements of cerebral perfusion or from the EEG. We will specifically test the hypotheses that septic encephalopathy may not be predicted by changes in the EEG, and that cerebrovascular autoregulation is not dysfunctional in septic encephalopathy.

Detailed Description

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Conditions

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Sepsis

Keywords

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sepsis encephalopathy cerebral perfusion electroencephalogram

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Sepsis
* Admission to ICU

Exclusion Criteria

* CNS infection
* History of cerebrovascular disease

Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Luzius A Steiner, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesia, University of Basel Hospital, Basel, Switzerland

Locations

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Operative Intensivbehandlung, University of Basel Hospital

Basel, , Switzerland

Site Status

Countries

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Switzerland

References

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Pfister D, Siegemund M, Dell-Kuster S, Smielewski P, Ruegg S, Strebel SP, Marsch SC, Pargger H, Steiner LA. Cerebral perfusion in sepsis-associated delirium. Crit Care. 2008;12(3):R63. doi: 10.1186/cc6891. Epub 2008 May 5.

Reference Type DERIVED

PMID: 18457586 (View on PubMed)

Other Identifiers

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EKBB 226/06

Identifier Type: -

Identifier Source: org_study_id