Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

NCT ID: NCT00410111

Last Updated: 2008-10-16

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 23 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2007-01-31
• Study Completion Date: 2007-07-31

Brief Summary

Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this condition have different patterns of cerebrovascular reactivity and whether it is possible to predict the development of septic encephalopathy from early measurements of cerebral perfusion or from the EEG. We will specifically test the hypotheses that septic encephalopathy may not be predicted by changes in the EEG, and that cerebrovascular autoregulation is not dysfunctional in septic encephalopathy.

Conditions

Sepsis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Sepsis
• Admission to ICU

Exclusion Criteria

• CNS infection
• History of cerebrovascular disease

• Minimum Eligible Age: 16 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital, Basel, Switzerland

OTHER

Sponsor Role: lead

Principal Investigators

Luzius A Steiner, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesia, University of Basel Hospital, Basel, Switzerland

Locations

Operative Intensivbehandlung, University of Basel Hospital

Basel, , Switzerland

Countries

Switzerland

References

Pfister D, Siegemund M, Dell-Kuster S, Smielewski P, Ruegg S, Strebel SP, Marsch SC, Pargger H, Steiner LA. Cerebral perfusion in sepsis-associated delirium. Crit Care. 2008;12(3):R63. doi: 10.1186/cc6891. Epub 2008 May 5.

Reference Type: DERIVED

PMID: 18457586 (View on PubMed)

Other Identifiers

EKBB 226/06

Identifier Type: -

Identifier Source: org_study_id