A Dose Finding Study of KRN321(Darbepoetin Alfa) for the Treatment of Anemia in Subjects With Solid Tumor

NCT ID: NCT00359840

Last Updated: 2012-08-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-07-31

Brief Summary

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To assess the clinical effective dose of KRN321 administered with once triweekly schedule.

Detailed Description

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Conditions

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Anemia

Keywords

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darbepoetin alfa anemia cancer patients chemotherapy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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darbepoetin alfa

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* patients diagnosed as solid tumor or malignant lymphoma
* patients receiving cyclic chemotherapy
* written informed consent
* hemoglobin concentration below 11 d/dL at enrollment
* life expectancy of more than 4 months

Exclusion Criteria

* hemolysis, gastrointestinal bleeding, postoperative bleeding
* iron deficiency
* megaloblastic anemia
* received \> 2 RBC transfusions within 4 weeks before randomization or any RBC transfusion within 2 weeks before randomization
* any primary hematological disorder that could cause anemia
* prior treatment with KRN321
* received erythropoetin therapy within 8 weeks before treatment
Minimum Eligible Age

20 Years

Maximum Eligible Age

74 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kyowa Kirin Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nagahiro Saijo, MD

Role: STUDY_CHAIR

National Cancer Center Hospital East

Locations

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Tokai region

Aichi, , Japan

Site Status

Shikoku region

Ehime, , Japan

Site Status

Kyusyu region

Fukuoka, Kumamoto, , Japan

Site Status

Hokkaido region

Hokkaido, , Japan

Site Status

Kinki region

Kyoto, Osaka, Nara, , Japan

Site Status

Tohoku region

Miyagi, , Japan

Site Status

Hokuriku region

Niigata, Ishikawa, , Japan

Site Status

Kanto region

Tochigi, Saitama, Tokyo, Kanagawa, , Japan

Site Status

Countries

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Japan

Other Identifiers

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KRN321-SC/05-A55

Identifier Type: -

Identifier Source: org_study_id