Observational Study of Correction of Anaemia With Darbepoetin Alfa at QM Dosing Interval in Patients With CKD Not on Dialysis

NCT ID: NCT02185911

Last Updated: 2016-03-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

308 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-30

Study Completion Date

2015-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To describe anaemia correction via haemoglobin measurements taken throughout observation period in ESA naive patients with chronic kidney disease initiated on darbepoetin alfa QM

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Darbepoetin alfa (Aranesp) is a long-acting ESA approved for treatment of anaemia in CKD patients, and may be administered once a week (QW), once every two weeks (Q2W) or once a month (QM) for correction and for maintenance in CKD patients not on dialysis. Prescribing information for darbepoetin alfa was updated in August 2013 (in EU and Australia), to incorporate the option for correction at QM dosing frequency in CKD patients not on dialysis. There is very little published literature describing QM correction in a real-world setting.

Data obtained from this study are intended to contribute to filling a literature gap and to provide a robust source of information for physicians.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Anaemia Chronic Kidney Disease (CKD)

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Cohort 1

Patients with CKD

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Patients ≥18 years of age.
2. Patients with CKD:

1. Not on dialysis at time of darbepoetin alfa initiation at QM dosing frequency.
2. Hb \<10g/dL immediately prior to initiation of darbepoetin alfa at QM dosing.
3. Commenced darbepoetin alfa at QM dosing frequency during or after August 2013.
4. Received at least three consecutive doses of darbepoetin alfa at QM dosing frequency, being the initiation dose and two further doses at QM dosing frequency.
3. Patient or patient's legally acceptable representative has provided informed consent, if applicable according to local requirements.

Exclusion Criteria

1. Treatment with an ESA within 14 weeks prior to initiation of darbepoetin alfa.
2. Patient was enrolled in an interventional device or drug study at any time during the 46-week data observation period or within 30 days prior to commencement of the data observtion period.
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Amgen

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

MD

Role: STUDY_DIRECTOR

Amgen

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Research Site

Feldkirch, , Austria

Site Status

Research Site

Linz, , Austria

Site Status

Research Site

Vienna, , Austria

Site Status

Research Site

Dobrich, , Bulgaria

Site Status

Research Site

Montana, , Bulgaria

Site Status

Research Site

Pazardzhik, , Bulgaria

Site Status

Research Site

Plovdiv, , Bulgaria

Site Status

Research Site

Plovdiv, , Bulgaria

Site Status

Research Site

Plovdiv, , Bulgaria

Site Status

Research Site

Sofia, , Bulgaria

Site Status

Research Site

Sofia, , Bulgaria

Site Status

Research Site

Varna, , Bulgaria

Site Status

Research Site

Vratsa, , Bulgaria

Site Status

Research Site

Brno, , Czechia

Site Status

Research Site

Havlíčkův Brod, , Czechia

Site Status

Research Site

Nové Město na Moravě, , Czechia

Site Status

Research Site

Třebíč, , Czechia

Site Status

Research Site

Athens, , Greece

Site Status

Research Site

Athens, , Greece

Site Status

Research Site

Pátrai, , Greece

Site Status

Research Site

Thessaloniki, , Greece

Site Status

Research Site

Thessaloniki, , Greece

Site Status

Research Site

Baja, , Hungary

Site Status

Research Site

Kecskemét, , Hungary

Site Status

Research Site

Szeged, , Hungary

Site Status

Research Site

Szigetvár, , Hungary

Site Status

Research Site

Szombathely, , Hungary

Site Status

Research Site

Zalaegerszeg, , Hungary

Site Status

Research Site

Albano Laziale RM, , Italy

Site Status

Research Site

Lodz, , Poland

Site Status

Research Site

Lodz, , Poland

Site Status

Research Site

Lublin, , Poland

Site Status

Research Site

Poznan, , Poland

Site Status

Research Site

Sieradz, , Poland

Site Status

Research Site

Stalowa Wola, , Poland

Site Status

Research Site

Córdoba, Andalusia, Spain

Site Status

Research Site

Badalona, Catalonia, Spain

Site Status

Research Site

Barcelona, Catalonia, Spain

Site Status

Research Site

Valencia, Valencia, Spain

Site Status

Research Site

Valencia, Valencia, Spain

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Austria Bulgaria Czechia Greece Hungary Italy Poland Spain

Related Links

Access external resources that provide additional context or updates about the study.

http://www.amgentrials.com

AmgenTrials clinical trials website

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

20130301

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.