A Proof-of-Concept Study of Darbepoetin Alfa in Partial Correction of Anemia in Chinese With Diabetic Nephropathy

NCT ID: NCT00907608

Last Updated: 2009-05-22

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-12-31
• Study Completion Date: 2009-05-31

Brief Summary

The purpose of this study is to examine the effect of partial correction of anemia with Darbepoetin alfa to a target of 11 g.dL (female) or 12 g/dL (male) on the reduction of cardiovascular morbidity and total mortality.

Detailed Description

Diabetes is the leading cause of end stage renal disease and cardiovascular disease with 60 percent of the global diabetic population coming from Asia. Growing evidence confirms the predictive role of chronic kidney disease (CKD) on cardiovascular morbidity and mortality. This is due to the constellation of conventional and non-conventional risk factors in patients who develop CKD, such as anemia, inflammation and abnormal bone metabolism. In this regard, anemia is a risk factor for cardiovascular disease and all-cause mortality in patients with CKD, patients with left ventricular dysfunction and in general population.

Effective erythropoiesis is dependent on the production of erythropoietin by the kidneys. Anemia is a common finding in patients with diabetes and up to 20% of diabetic patients are noted to have anemia. In a meta-analysis of community-based population studies, anemia interacts with CKD to increase the risk of coronary heart disease, stroke and all-cause mortality among patients with diabetes. Previous studies that examined the effect of erythropoietin therapy on anemic subjects with CKD did not find statistical difference in mortality rates between the treated and untreated groups. Possible explanations for the lack of benefits include higher level of blood pressure and increased blood viscosity leading to worsening of chronic congestive heart failure in the treated subjects. We hypothesize that partial correction of hemoglobin may be more appropriate.

Conditions

Diabetes Mellitus; Chronic Kidney Disease; Anemia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

1

Receive Darbepoetin alfa

Group Type: EXPERIMENTAL

Darbepoetin alfa

Intervention Type: DRUG

Starting dose of 20 microgram per week, to be titrated over a 3-month period until target hemoglobin level is reached (female: 11 g/dL and male: 12 g/dL). Route of administration is subcutaneous injection.

2

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Darbepoetin alfa

Starting dose of 20 microgram per week, to be titrated over a 3-month period until target hemoglobin level is reached (female: 11 g/dL and male: 12 g/dL). Route of administration is subcutaneous injection.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Male or female patients aged above 20 years old
• Patients with Type 1 or Type 2 diabetes mellitus
• Estimated glomerular filtration rate less than 59 mL/min/1.73m2
• Patients not on renal replacement therapy
• Hemoglobin level at baseline : women less than 9.5 g/dL (inclusive) and men less than 10.5 g/dL (inclusive)
• All patients should be on a stable dose of the following medications 4 weeks before enrolment :
• Aspirin 80mg daily unless contraindicated
• Statin to achieve stable and optimal LDL-cholesterol level
• Maximal tolerated dose of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers
• Anti-hypertensive treatment to maintain blood pressure target of less than 130/80 mmHg or a level achieved without undue side effects
• Oral anti-diabetic drugs or insulin to maintain HbA1C less than 9.5%

Exclusion Criteria

• Pregnancy, breast feeding or patient has plans of becoming pregnant during the study period
• Known non-diabetic renal disease
• Known cause of anemia not related to chronic kidney disease
• Presence of hemoglobinopathy
• History of pure red cell aplasia
• Known allergy to Darbepoetin alfa
• Severe liver impairment (>= 3x ULN of ALT)
• Poorly controlled hypertension, systolic BP >= 160mmHg or diastolic BP >= 100mmHg
• Significant cardiovascular disease within 3 months of enrolment including acute coronary syndrome, cardiac revascularization procedure, transient ischemic attack and cerebrovascular accident
• History of major gastrointestinal bleeding in the 5 years prior to consent
• Investigational drugs within 30 days of enrolment
• Any other medical conditions that is considered as unsuitable for the study by investigator

• Minimum Eligible Age: 20 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chinese University of Hong Kong

OTHER

Sponsor Role: lead

Responsible Party

Chinese University of Hong Kong

Principal Investigators

Peter CY Tong, MBChB

Role: PRINCIPAL_INVESTIGATOR

Chinese University of Hong Kong

Locations

Prince of Wales Hospital

Hong Kong, , China

Countries

China

Other Identifiers

PWH-2008-darbe

Identifier Type: -

Identifier Source: org_study_id