Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest
NCT ID: NCT00358579
Last Updated: 2017-03-17
Study Results
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View full resultsBasic Information
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COMPLETED
PHASE3
727 participants
INTERVENTIONAL
2006-03-31
2010-01-31
Brief Summary
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Thus the purpose of this study is to compare vasopressin and adrenaline in the treatment of cardiac arrest to answer the question whether there is an improvement in survival between vasopressin and adrenaline.
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Detailed Description
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More recently, vasopressin has been used in patients with cardiac arrest. In human studies on vasopressin, clinical trials have produced conflicting results.
The current study compared vasopressin and adrenaline in the treatment of cardiac arrest in patients presenting to the Emergency Department (ED). Specific outcomes included return of spontaneous circulation (ROSC) (as measured by the presence of a palpable pulse at any time during resuscitation), survival to hospital admission, survival to discharge from hospital, and functional status at discharge and at one year (as measured by the Glasgow-Pittsburgh outcome categories).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Adrenaline
Adrenaline
1 mg
Vasopressin
Vasopressin
40 IU
Interventions
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Adrenaline
1 mg
Vasopressin
40 IU
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age above 16 (Age 21 and above for CGH only)
Exclusion Criteria
* Age 16 and below (Age 20 and below for CGH only)
* CPR is contraindicated
17 Years
ALL
No
Sponsors
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National Medical Research Council (NMRC), Singapore
OTHER_GOV
Alexandra Hospital
OTHER
National University Hospital, Singapore
OTHER
Changi General Hospital
OTHER
Singapore General Hospital
OTHER
Responsible Party
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Principal Investigators
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Marcus EH Ong, MBBS
Role: PRINCIPAL_INVESTIGATOR
Singapore General Hospital
Locations
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National University Hospital
Singapore, , Singapore
Alexandra Hospital
Singapore, , Singapore
Singapore General Hospital
Singapore, , Singapore
Changi General Hospital
Singapore, , Singapore
Countries
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References
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Ong ME, Tiah L, Leong BS, Tan EC, Ong VY, Tan EA, Poh BY, Pek PP, Chen Y. A randomised, double-blind, multi-centre trial comparing vasopressin and adrenaline in patients with cardiac arrest presenting to or in the Emergency Department. Resuscitation. 2012 Aug;83(8):953-60. doi: 10.1016/j.resuscitation.2012.02.005. Epub 2012 Feb 18.
Other Identifiers
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SQCA01
Identifier Type: -
Identifier Source: org_study_id
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