Norepinephrine and Phenylephrine, Which Better for Elderly?
NCT ID: NCT04067817
Last Updated: 2019-10-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE3
100 participants
INTERVENTIONAL
2019-10-06
2020-01-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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norepinephrine
Blood pressure is generally maintained at value not less than 80% of baseline during intraoperative period. If the blood pressure is within normal range and SVV is less than 9, patient will be given a continuous infusion of crystalloid solution. However, when blood pressure drops and SVV is greater than 13, a bolus of 200mL colloid will then be quickly administered. If the blood pressure doesn't recover back to normal range within 5 minutes after bolus, norepinephrine will be given through the central venous catheter. If SVV is between 9 and 13, a bolus of crystalloid at 8mL/kg/h will be administered
norepinephrine
patient who was received the treatment of norepinephrine
phenylephrine
Blood pressure is generally maintained at value not less than 80% of baseline during intraoperative period. If the blood pressure is within normal range and SVV is less than 9, patient will be given a continuous infusion of crystalloid solution. However, when blood pressure drops and SVV is greater than 13, a bolus of 200mL colloid will then be quickly administered. If the blood pressure doesn't recover back to normal range within 5 minutes after bolus, phenylephrine will be given through the central venous catheter. If SVV is between 9 and 13, a bolus of crystalloid at 8mL/kg/h will be administered.
Phenylephrine
patient who was received the treatment of phenylephrine
Interventions
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norepinephrine
patient who was received the treatment of norepinephrine
Phenylephrine
patient who was received the treatment of phenylephrine
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* age over 65 years old,
* surgical time longer than 2hours,
* the American Society of Anesthesiologists(ASA) classification of II or III
Exclusion Criteria
* history of severe liver and kidney diseases,
* evidence of arrhythmia on EKG,
* use of positive end-expiratory pressure (PEEP) during mechanical ventilation;
* conditions with relative contraindication for arterial catheterization
60 Years
95 Years
ALL
Yes
Sponsors
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The Second Affiliated Hospital of Dalian Medical University
OTHER
Responsible Party
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Principal Investigators
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xiao z yang, MD,PhD
Role: STUDY_DIRECTOR
The Second Affiliated Hospital of Dalian Medical University
Locations
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The Second Hospital of Dalian Medical University
Dalian, Liaoning, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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poster2016
Identifier Type: -
Identifier Source: org_study_id
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