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Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery

NCT ID: NCT00294606

Last Updated: 2006-02-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

86 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-02-28

Study Completion Date

2006-02-28

Brief Summary

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This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia. The effect of the vasopressor on cardiac function will be measured using electrocardiography, transesophageal echocardiography and cardiac troponin I intraoperatively and postoperatively. We will use a cross-over pattern since both drugs exhibit rapid onset and short duration of action. We hypothesize that there will be less myocardial ischemia associated with the use of norepinephrine when compared with phenylephrine during carotid artery surgery.

Detailed Description

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Conditions

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Vasopressor Agents Endarterectomy, Carotid Echocardiography, Transesophageal

Keywords

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vasopressor agents carotid endarterectomy cardiac function transesophageal echocardiography wall motion abnormalities

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

DOUBLE

Interventions

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Comparison of Effects of Phenylephrine and Norepinephrine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Elective carotid endarterectomy under general anesthesia
* \> 18 years old
* Written informed consent

Exclusion Criteria

* Contraindication to general anesthesia
* Contraindication to transesophageal anesthesia
* esophageal disease
* esophageal stricture
* history of esophageal or gastric bleeding
* esophageal anatomic abnormality
* past esophageal or gastric surgery
* severe dysphagia
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

OTHER

Sponsor Role lead

Principal Investigators

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Rosemary A Craen, MD, FRCPC

Role: PRINCIPAL_INVESTIGATOR

Associate Professor University of Western Ontario

Locations

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University Hospital, LHSC

London, Ontario, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Rosemary A Craen, MD, FRCPC

Role: CONTACT

Phone: (519) 663-3022

Email: [email protected]

Hélène G Pellerin, MD, FRCPC

Role: CONTACT

Phone: (519) 663-3022

Email: [email protected]

Facility Contacts

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Rosemary A Craen, MD, FRCPC

Role: primary

Other Identifiers

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R-05-941

Identifier Type: -

Identifier Source: org_study_id