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Observational Study of Iron Metabolism in Anemia in ICU and Post-Operative Patients

NCT ID: NCT00338234

Last Updated: 2008-05-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

153 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-06-30

Study Completion Date

2007-12-31

Brief Summary

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Anemia in intensive care and post-operative patients is due to both blood loss (leading to iron loss) and inflammation.

Detailed Description

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Anemia in intensive care and post-operative patients is due to both blood loss (leading to iron loss) and inflammation. The latter is known to interfere with iron metabolism, inducing iron storage instead of using it for hemoglobin synthesis. The discover of a new regulatory hormone of iron metabolism, hepcidin, may help us to better understand the link between inflammation and iron functional deficit. The aim of our study is to observe the variation of usual iron metabolism biological markers and of hepcidin, in order to define the better marker of iron loss in these clinical situations.

Conditions

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Anemia Intensive Care Cardiac Surgery

Keywords

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anemia intensive care cardiac surgery iron metabolism hepcidin

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Cardiac surgery

Successive cardiac surgery patients

No interventions assigned to this group

Surgical ICU

Successive patients admitted to the surgical ICU for more than 7 days, and experiencing anemia

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Anemia (haemoglobin \< 10 g/dL)
* Hospitalization in ICU for an expected duration of 7 days or more
* Or, day one post cardiac surgery

Exclusion Criteria

* Chronic anemia (Hb \< 9 g/dL for more than one month before hospitalization)
* Iron metabolism disease
Minimum Eligible Age

20 Years

Maximum Eligible Age

88 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Société Française d'Anesthésie et de Réanimation

OTHER

Sponsor Role collaborator

Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role collaborator

Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role lead

Responsible Party

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CHU BICHAT-Claude BERNARD

Principal Investigators

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sigismond lasocki, MD

Role: PRINCIPAL_INVESTIGATOR

Assistance Publique - Hôpitaux de Paris

Carole Beaumont, PhD

Role: STUDY_CHAIR

Institut National de la Santé Et de la Recherche Médicale, France

Isabelle Boutron, MD

Role: STUDY_CHAIR

Institut National de la Santé Et de la Recherche Médicale, France

Locations

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APHP, hopital Bichat

Paris, , France

Site Status

Countries

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France

Other Identifiers

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FAIRe

Identifier Type: -

Identifier Source: org_study_id