Noninvasive Hemoglobin Monitoring for Maintaining Hemoglobin Concentration Within the Target Range

NCT ID: NCT03816514

Last Updated: 2020-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

130 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-04

Study Completion Date

2020-11-06

Brief Summary

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The primary aim of this study is to evaluate whether pulse oximetry based noninvasive hemoglobin (SpHb) monitoring can reduce the incidence of hemoglobin (Hb) level out of the target range in adult patients undergoing major surgery with the potential risk of bleeding.

Detailed Description

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Conditions

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Hemoglobins Blood Transfusion Hemorrhage

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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SpHb monitoring group

In SpHb monitoring group, noninvasive, continuous SpHb monitoring will be done using Radical-7 pulse CO-Oximeter. The patients will be managed according to the prespecified protocol based on the SpHb values.

Group Type EXPERIMENTAL

SpHb monitoring

Intervention Type PROCEDURE

Noninvasive, continuous pulse oximetry-based hemoglobin (SpHb) monitoring

Control group

In control group, patients will receive conventional management without the SpHb monitoring. In these patients, the information about hemoglobin concentration of the patients will be obtained from hemoglobin measurement analyzed by point-of-care (POC) equipment, as usual standard care.

Group Type ACTIVE_COMPARATOR

Conventional management

Intervention Type PROCEDURE

Conventional management without SpHb monitoring

Interventions

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SpHb monitoring

Noninvasive, continuous pulse oximetry-based hemoglobin (SpHb) monitoring

Intervention Type PROCEDURE

Conventional management

Conventional management without SpHb monitoring

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Adult patients with ASA physical status class I, II, III, who scheduled to undergo elective non-cardiac major surgery with more than moderate risk of bleeding under general anesthesia or spinal anesthesia.
* Eligible Surgery include: Spine surgery, bone tumor surgery, Total Hip Replacement, ovarian cancer surgery, cervical cancer surgery, radical cystectomy, open retroperitoneal mass excision, Radical Retropubic Prostatectomy, explorative laparotomy for abdominal mass excision, abdominal aortic aneurysm repair
* Patients who are requiring an arterial catheter as a part of their standard care.

Exclusion Criteria

* Patients with preexisting deformity or skin condition that would impede sensor placement
* Patients with allergies to the adhesive sensor material
* Patients with uncorrected preoperative anemia (preoperative hemoglobin \< 7 g/dL)
* Patients who were not suitable for participation in the opinion of the study investigator.
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jin-Tae Kim

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jin-Tae Kim, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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Seoul national university hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Berkow L, Rotolo S, Mirski E. Continuous noninvasive hemoglobin monitoring during complex spine surgery. Anesth Analg. 2011 Dec;113(6):1396-402. doi: 10.1213/ANE.0b013e318230b425. Epub 2011 Sep 29.

Reference Type BACKGROUND
PMID: 21965372 (View on PubMed)

Causey MW, Miller S, Foster A, Beekley A, Zenger D, Martin M. Validation of noninvasive hemoglobin measurements using the Masimo Radical-7 SpHb Station. Am J Surg. 2011 May;201(5):592-8. doi: 10.1016/j.amjsurg.2011.01.020.

Reference Type BACKGROUND
PMID: 21545905 (View on PubMed)

Galvagno SM Jr, Hu P, Yang S, Gao C, Hanna D, Shackelford S, Mackenzie C. Accuracy of continuous noninvasive hemoglobin monitoring for the prediction of blood transfusions in trauma patients. J Clin Monit Comput. 2015 Dec;29(6):815-21. doi: 10.1007/s10877-015-9671-1. Epub 2015 Mar 10.

Reference Type BACKGROUND
PMID: 25753142 (View on PubMed)

Park SK, Hur C, Kim YW, Yoo S, Lim YJ, Kim JT. Noninvasive hemoglobin monitoring for maintaining hemoglobin concentration within the target range during major noncardiac surgery: A randomized controlled trial. J Clin Anesth. 2024 May;93:111326. doi: 10.1016/j.jclinane.2023.111326. Epub 2023 Nov 20.

Reference Type DERIVED
PMID: 37988814 (View on PubMed)

Other Identifiers

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H-1811-039-986

Identifier Type: -

Identifier Source: org_study_id